| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 74-58 | @ | Tulane | 7-22 | |
| 11/17/2009 | W 46-45 | Temple | 28-4 | ||
| 11/21/2009 | W 63-44 | @ | Savannah St | 7-15 | |
| 11/28/2009 | W 98-64 | Lafayette | 19-13 | ||
| 11/30/2009 | W 83-62 | Mt St. Mary's | 17-14 | ||
| 12/5/2009 | W 73-46 | American | 11-20 | ||
| 12/8/2009 | W 72-65 | vs | Butler | 28-3 | Jimmy V Classic |
| 12/12/2009 | W 74-66 | vs | Washington | 24-8 | Wooden Classic |
| 12/19/2009 | L 57-61 | Old Dominion | 24-9 | ||
| 12/23/2009 | W 86-70 | Harvard | 20-6 | ||
| 12/31/2009 | W 66-59 | St. John's | 16-15 | ||
| 1/3/2010 | W 67-50 | @ | DePaul | 8-22 | |
| 1/6/2010 | L 59-62 | @ | Marquette | 22-9 | |
| 1/9/2010 | W 72-69 | Connecticut | 18-13 | ||
| 1/14/2010 | W 85-73 | Seton Hall | 18-12 | ||
| 1/17/2010 | L 77-82 | at | Villanova | 23-5 | |
| 1/20/2010 | W 74-66 | @ | Pittsburgh | 24-7 | |
| 1/23/2010 | W 88-63 | Rutgers | 13-16 | ||
| 1/25/2010 | L 56-73 | @ | Syracuse | 26-2 | |
| 1/30/2010 | W 89-77 | Duke | 29-4 | ||
| 2/3/2010 | L 64-72 | South Florida | 18-11 | ||
| 2/6/2010 | W 103-90 | Villanova | 23-5 | ||
| 2/9/2010 | W 79-70 | @ | Providence | 12-18 | |
| 2/14/2010 | L 68-71 | @ | Rutgers | 13-16 | |
| 2/18/2010 | L 71-75 | Syracuse | 26-2 | ||
| 2/23/2010 | W 70-60 | @ | Louisville | 20-11 | |
| 2/27/2010 | L 64-78 | Notre Dame | 21-11 | ||
| 3/1/2010 | L 68-81 | @ | West Virginia | 25-6 | |
| 3/6/2010 | W 103-90 | Villanova | 23-5 | ||
| 3/10/2010 | W 69-49 | vs | South Florida | 18-11 | Big East |
| 3/11/2010 | W 91-84 | vs | Syracuse | 26-2 | Big East |
| 3/12/2010 | W 80-57 | vs | Marquette | 22-9 | Big East |
| 3/13/2010 | L 58-60 | vs | West Virginia | 25-6 | Big East |
| 23-10 | 478-276 |