| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 63-60 | Wofford | 25-7 | ||
| 11/17/2009 | W 71-46 | Binghamton | 11-18 | CBE Classic | |
| 11/19/2009 | W 71-60 | Eastern Kentucky | 19-11 | CBE Classic | |
| 11/23/2009 | W 68-55 | vs | Wichita St | 23-8 | CBE Classic |
| 11/24/2009 | L 62-78 | vs | Texas | 23-9 | CBE Classic |
| 11/28/2009 | W 72-56 | Youngstown St | 6-22 | ||
| 12/2/2009 | W 67-58 2 OT | @ | Duquesne | 15-14 | |
| 12/4/2009 | W 47-32 | New Hampshire | 11-17 | ||
| 12/8/2009 | L 64-74 | vs | Indiana | 8-21 | |
| 12/12/2009 | W 71-59 | Kent St | 22-8 | ||
| 12/19/2009 | W 66-48 | Mt St. Mary's | 17-14 | ||
| 12/22/2009 | W 74-49 | Ohio | 20-14 | ||
| 12/28/2009 | W 65-52 | DePaul | 8-22 | ||
| 1/2/2010 | W 82-72 | @ | Syracuse | 28-2 | |
| 1/4/2010 | W 74-71 | @ | Cincinnati | 18-13 | |
| 1/13/2010 | W 67-57 | @ | Connecticut | 18-13 | |
| 1/16/2010 | W 82-77 OT | Louisville | 20-11 | ||
| 1/20/2010 | L 66-74 | Georgetown | 22-10 | ||
| 1/24/2010 | L 61-64 | @ | Seton Hall | 17-11 | |
| 1/28/2010 | W 63-53 | St. John's | 16-14 | ||
| 1/31/2010 | L 61-70 | @ | South Florida | 18-12 | |
| 2/3/2010 | L 51-70 | @ | West Virginia | 26-5 | |
| 2/6/2010 | W 83-58 | Seton Hall | 17-11 | ||
| 2/8/2010 | W 77-53 | Robert Morris | 24-10 | ||
| 2/12/2010 | W 98-95 3 OT | West Virginia | 26-5 | ||
| 2/18/2010 | W 58-51 | @ | Marquette | 23-9 | |
| 2/21/2010 | W 70-65 | Villanova | 24-6 | ||
| 2/24/2010 | L 53-68 | @ | Notre Dame | 20-11 | |
| 2/27/2010 | W 71-64 | @ | St. John's | 16-14 | |
| 3/4/2010 | W 73-71 | Providence | 12-18 | ||
| 3/6/2010 | W 83-58 | Seton Hall | 17-11 | ||
| 3/11/2010 | L 45-50 | vs | Notre Dame | 20-11 | Big East |
| 24-8 | 494-330 |