| Date | Res | Opp | OW-OL | ||
| 11/14/2009 | W 76-56 | @ | Delaware | 7-22 | Philly Classic |
| 11/17/2009 | L 45-46 | @ | Georgetown | 22-10 | |
| 11/21/2009 | W 73-69 | Siena | 27-5 | Philly Classic | |
| 11/24/2009 | W 66-46 | Ball State | 14-15 | ||
| 11/27/2009 | W 61-50 | vs | Virginia Tech | 23-7 | Philly Classic |
| 11/28/2009 | L 48-55 | vs | St. John's | 15-16 | Philly Classic |
| 12/1/2009 | W 76-70 | @ | Western Michigan | 18-14 | |
| 12/5/2009 | W 45-42 | Penn State | 11-19 | ||
| 12/8/2009 | W 64-42 | @ | Miami-Ohio | 15-17 | |
| 12/13/2009 | W 75-65 | Villanova | 24-6 | ||
| 12/19/2009 | W 71-65 | @ | Seton Hall | 18-12 | |
| 12/28/2009 | W 63-39 | Bowling Green | 13-16 | ||
| 12/30/2009 | W 70-60 | @ | Northern Illinois | 10-20 | |
| 1/2/2010 | L 52-84 | Kansas | 31-2 | ||
| 1/6/2010 | W 73-46 | Saint Joseph's | 10-18 | ||
| 1/10/2010 | W 68-64 OT | @ | Rhode Island | 24-5 | |
| 1/13/2010 | W 60-45 | @ | Pennsylvania | 6-21 | |
| 1/16/2010 | W 76-64 | Massachusetts | 10-20 | ||
| 1/20/2010 | W 77-72 | Xavier | 23-8 | ||
| 1/23/2010 | W 62-45 | @ | Fordham | 2-25 | |
| 1/27/2010 | L 64-74 | @ | Charlotte | 19-12 | |
| 1/30/2010 | W 64-52 | La Salle | 12-16 | ||
| 2/3/2010 | W 76-60 | Duquesne | 15-14 | ||
| 2/6/2010 | L 54-71 | @ | Richmond | 25-7 | |
| 2/13/2010 | W 78-56 | Rhode Island | 24-5 | ||
| 2/17/2010 | W 73-55 | @ | St. Bonaventure | 14-13 | |
| 2/20/2010 | W 75-67 OT | @ | Saint Joseph's | 10-18 | |
| 2/24/2010 | W 49-41 | Dayton | 21-10 | ||
| 2/28/2010 | W 65-53 | @ | La Salle | 12-16 | |
| 3/3/2010 | W 57-51 | @ | Saint Louis | 19-10 | |
| 3/12/2010 | W 69-51 | vs | St. Bonaventure | 14-13 | Atlantic 10 |
| 3/13/2010 | W 57-44 | vs | Rhode Island | 24-5 | Atlantic 10 |
| 3/14/2010 | W 56-52 | vs | Richmond | 25-7 | Atlantic 10 |
| 28-5 | 448-360 |