| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 67-61 | @ | SMU | 13-15 | |
| 11/16/2009 | W 66-49 | Virginia | 15-15 | ||
| 11/19/2009 | W 65-58 | vs | Davidson | 15-13 | C of Charleston Classic |
| 11/20/2009 | L 66-69 | vs | South Carolina | 13-17 | C of Charleston Classic |
| 11/22/2009 | W 74-66 | vs | UNC Wilmington | 9-20 | C of Charleston Classic |
| 11/25/2009 | W 76-54 | Kent St | 22-8 | ||
| 11/27/2009 | W 78-58 | Florida Atlantic | 12-15 | ||
| 12/2/2009 | W 74-55 | Hampton | 14-18 | ||
| 12/13/2009 | L 56-59 | Central Michigan | 13-16 | ||
| 12/16/2009 | W 69-65 | UCF | 13-16 | ||
| 12/19/2009 | W 69-49 | vs | San Francisco | 10-17 | Las Vegas Tourney |
| 12/20/2009 | W 69-60 | vs | San Diego | 9-20 | Las Vegas Tourney |
| 12/30/2009 | L 52-73 | @ | Louisville | 19-12 | |
| 1/5/2010 | L 73-74 | Notre Dame | 20-11 | ||
| 1/10/2010 | L 65-82 | @ | Syracuse | 27-3 | |
| 1/13/2010 | L 50-69 | West Virginia | 26-6 | ||
| 1/16/2010 | W 73-64 | Rutgers | 14-16 | ||
| 1/20/2010 | L 70-78 | @ | Cincinnati | 17-13 | |
| 1/23/2010 | W 109-105 OT | @ | Providence | 12-17 | |
| 1/28/2010 | W 76-74 OT | Seton Hall | 18-12 | ||
| 1/31/2010 | W 70-61 | Pittsburgh | 24-7 | ||
| 2/3/2010 | W 72-64 | @ | Georgetown | 22-9 | |
| 2/7/2010 | L 62-65 | @ | Notre Dame | 20-11 | |
| 2/13/2010 | L 52-63 | @ | Marquette | 22-10 | |
| 2/16/2010 | W 65-57 | Cincinnati | 17-13 | ||
| 2/20/2010 | L 58-74 | St. John's | 15-16 | ||
| 2/24/2010 | L 49-74 | @ | Villanova | 23-7 | |
| 2/27/2010 | W 99-93 | Providence | 12-17 | ||
| 3/2/2010 | W 63-59 | @ | DePaul | 8-21 | |
| 3/9/2010 | W 58-49 | vs | DePaul | 8-21 | Big East |
| 3/10/2010 | L 49-69 | vs | Georgetown | 22-9 | Big East |
| 19-12 | 425-350 |