| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 75-66 | William & Mary | 21-9 | ||
| 11/16/2009 | W 77-63 | Colgate | 10-18 | NIT Tipoff | |
| 11/17/2009 | W 76-67 | Hofstra | 17-13 | NIT Tipoff | |
| 11/25/2009 | W 81-55 | vs | LSU | 10-20 | NIT Tipoff |
| 11/27/2009 | L 59-68 | vs | Duke | 28-5 | NIT Tipoff |
| 12/2/2009 | W 92-64 | Boston U | 19-12 | ||
| 12/6/2009 | W 79-73 | Harvard | 20-6 | ||
| 12/9/2009 | L 61-64 | vs | Kentucky | 32-2 | |
| 12/20/2009 | W 60-51 | UCF | 13-16 | ||
| 12/22/2009 | W 71-54 | Maine | 19-9 | ||
| 12/27/2009 | W 93-74 | Iona | 21-9 | ||
| 12/30/2009 | L 69-71 | @ | Cincinnati | 16-14 | |
| 1/2/2010 | W 82-70 | Notre Dame | 21-10 | ||
| 1/6/2010 | W 71-63 | Seton Hall | 18-12 | ||
| 1/9/2010 | L 69-72 | @ | Georgetown | 22-10 | |
| 1/13/2010 | L 57-67 | Pittsburgh | 23-8 | ||
| 1/17/2010 | L 63-68 | at | Michigan | 13-18 | |
| 1/20/2010 | W 75-59 | St. John's | 15-15 | ||
| 1/23/2010 | W 88-74 | Texas | 24-8 | ||
| 1/27/2010 | L 66-81 | @ | Providence | 11-19 | |
| 1/30/2010 | L 68-70 | Marquette | 22-10 | ||
| 2/1/2010 | L 69-82 | @ | Louisville | 18-12 | |
| 2/6/2010 | W 64-57 | DePaul | 8-21 | ||
| 2/10/2010 | L 67-72 | @ | Syracuse | 27-3 | |
| 2/13/2010 | L 48-60 | Cincinnati | 16-14 | ||
| 2/15/2010 | W 84-75 | @ | Villanova | 24-6 | |
| 2/20/2010 | W 76-58 | @ | Rutgers | 14-16 | |
| 2/22/2010 | W 73-62 | West Virginia | 27-5 | ||
| 2/28/2010 | L 76-78 | Louisville | 18-12 | ||
| 3/3/2010 | L 50-58 | @ | Notre Dame | 21-10 | |
| 3/6/2010 | W 64-57 | DePaul | 8-21 | ||
| 3/9/2010 | L 51-73 | @ | St. John's | 15-15 | Big East |
| 18-14 | 513-306 |