| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 83-70 | Long Island | 14-17 | ||
| 11/17/2009 | W 69-68 | @ | St. Bonaventure | 14-14 | |
| 11/20/2009 | W 79-76 | Brown | 9-19 | ||
| 11/27/2009 | W 77-68 | vs | Siena | 27-5 | Philly Classic |
| 11/28/2009 | W 55-48 | vs | Temple | 28-4 | Philly Classic |
| 12/2/2009 | W 63-55 | Stony Brook | 20-8 | ||
| 12/5/2009 | L 71-80 | @ | Duke | 28-5 | |
| 12/9/2009 | W 66-56 | Georgia | 15-15 | ||
| 12/13/2009 | W 73-56 | Fordham | 2-25 | ||
| 12/20/2009 | W 72-60 | Hofstra | 17-13 | MSG Holiday Festival | |
| 12/21/2009 | L 66-71 | Cornell | 24-4 | MSG Holiday Festival | |
| 12/23/2009 | W 80-44 | Bryant | 1-29 | ||
| 12/31/2009 | L 59-66 | @ | Georgetown | 22-10 | |
| 1/3/2010 | L 59-74 | Providence | 11-19 | ||
| 1/9/2010 | L 68-75 | @ | Louisville | 19-11 | |
| 1/13/2010 | W 52-50 | Cincinnati | 18-13 | ||
| 1/17/2010 | W 67-47 | at | DePaul | 8-22 | |
| 1/20/2010 | L 59-75 | @ | Connecticut | 17-13 | |
| 1/23/2010 | L 71-81 | Villanova | 23-7 | ||
| 1/28/2010 | L 53-63 | @ | Pittsburgh | 22-8 | |
| 2/2/2010 | L 72-84 | @ | Rutgers | 13-17 | |
| 2/6/2010 | L 60-79 | West Virginia | 25-6 | ||
| 2/11/2010 | W 74-55 | Louisville | 19-11 | ||
| 2/14/2010 | W 69-68 | @ | Notre Dame | 22-10 | |
| 2/17/2010 | L 50-59 | Seton Hall | 17-13 | ||
| 2/20/2010 | W 74-58 | @ | South Florida | 19-11 | |
| 2/24/2010 | L 61-63 OT | Marquette | 21-10 | ||
| 2/27/2010 | L 64-71 | Pittsburgh | 22-8 | ||
| 3/2/2010 | L 66-85 | @ | Syracuse | 27-3 | |
| 3/6/2010 | L 60-79 | West Virginia | 25-6 | ||
| 3/9/2010 | W 73-51 | Connecticut | 17-13 | Big East | |
| 3/10/2010 | L 55-57 | Marquette | 21-10 | Big East | |
| 16-16 | 483-331 |