| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 53-51 | St. Peter's | 16-13 | ||
| 11/15/2009 | W 87-72 | @ | Monmouth | 12-19 | |
| 11/20/2009 | W 89-79 | @ | Cornell | 25-3 | |
| 11/28/2009 | W 95-66 | Long Island | 14-17 | ||
| 11/30/2009 | W 93-53 | NJIT | 7-20 | ||
| 12/3/2009 | W 89-56 | Hartford | 9-20 | ||
| 12/7/2009 | W 86-68 | Massachusetts | 10-20 | ||
| 12/12/2009 | W 134-107 | VMI | 6-19 | ||
| 12/19/2009 | L 65-71 | Temple | 27-5 | ||
| 12/22/2009 | W 94-56 | Navy | 14-16 | ||
| 12/26/2009 | L 84-90 OT | at | West Virginia | 25-6 | |
| 12/29/2009 | L 73-80 | Syracuse | 27-3 | ||
| 1/2/2010 | L 94-103 OT | vs | Virginia Tech | 22-8 | |
| 1/6/2010 | L 63-71 | @ | Connecticut | 17-14 | |
| 1/9/2010 | W 83-76 | Cincinnati | 18-13 | ||
| 1/14/2010 | L 73-85 | @ | Georgetown | 22-10 | |
| 1/21/2010 | W 80-77 | Louisville | 20-11 | ||
| 1/24/2010 | W 64-61 | Pittsburgh | 22-7 | ||
| 1/28/2010 | L 74-76 OT | @ | South Florida | 18-12 | |
| 2/2/2010 | L 71-81 | @ | Villanova | 23-7 | |
| 2/6/2010 | L 58-83 | @ | Pittsburgh | 22-7 | |
| 2/11/2010 | W 90-87 | Notre Dame | 21-10 | ||
| 2/14/2010 | W 79-71 | DePaul | 8-22 | ||
| 2/17/2010 | W 59-50 | @ | St. John's | 16-15 | |
| 2/20/2010 | L 63-75 | @ | West Virginia | 25-6 | |
| 2/23/2010 | W 76-70 | Rutgers | 14-15 | ||
| 2/28/2010 | L 83-84 OT | Marquette | 22-10 | ||
| 3/4/2010 | W 85-74 | @ | Rutgers | 14-15 | |
| 3/6/2010 | L 58-83 | @ | Pittsburgh | 22-7 | |
| 3/9/2010 | W 109-106 | vs | Providence | 12-18 | Big East |
| 3/10/2010 | L 56-68 | vs | Notre Dame | 21-10 | Big East |
| 18-13 | 447-333 |