| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 84-61 | Fairleigh Dickinson | 12-20 | ||
| 11/16/2009 | W 103-65 | Pennsylvania | 6-21 | ||
| 11/19/2009 | W 69-68 | vs | George Mason | 17-13 | Puerto Rico Shootout |
| 11/20/2009 | W 71-65 | vs | Dayton | 21-10 | Puerto Rico Shootout |
| 11/22/2009 | W 79-67 | vs | Mississippi | 21-9 | Puerto Rico Shootout |
| 11/28/2009 | W 81-63 | La Salle | 12-17 | ||
| 12/2/2009 | W 77-58 | Drexel | 17-14 | ||
| 12/6/2009 | W 95-86 | vs | Maryland | 21-7 | |
| 12/9/2009 | W 97-89 | @ | Saint Joseph's | 10-19 | |
| 12/13/2009 | L 65-75 | @ | Temple | 27-5 | |
| 12/19/2009 | W 96-58 | @ | Fordham | 2-25 | |
| 12/23/2009 | W 97-63 | Delaware | 7-22 | ||
| 1/2/2010 | W 74-72 | @ | Marquette | 22-8 | |
| 1/6/2010 | W 99-72 | DePaul | 8-22 | ||
| 1/9/2010 | W 78-76 | Marquette | 22-8 | ||
| 1/11/2010 | W 92-84 | @ | Louisville | 20-11 | |
| 1/17/2010 | W 82-77 | at | Georgetown | 21-9 | |
| 1/20/2010 | W 94-68 | @ | Rutgers | 14-16 | |
| 1/23/2010 | W 81-71 | @ | St. John's | 16-15 | |
| 1/27/2010 | W 90-72 | Notre Dame | 22-10 | ||
| 2/2/2010 | W 81-71 | Seton Hall | 18-12 | ||
| 2/6/2010 | L 90-103 | @ | Georgetown | 21-9 | |
| 2/8/2010 | W 82-75 | @ | West Virginia | 27-5 | |
| 2/13/2010 | W 92-81 | Providence | 12-18 | ||
| 2/15/2010 | L 75-84 | Connecticut | 17-14 | ||
| 2/21/2010 | L 65-70 | @ | Pittsburgh | 23-8 | |
| 2/24/2010 | W 74-49 | South Florida | 19-11 | ||
| 2/27/2010 | L 77-95 | @ | Syracuse | 27-3 | |
| 3/2/2010 | W 77-73 | @ | Cincinnati | 18-13 | |
| 3/6/2010 | L 90-103 | @ | Georgetown | 21-9 | |
| 3/11/2010 | L 76-80 | vs | Marquette | 22-8 | Big East |
| 24-7 | 457-357 |