| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | L 58-74 | Georgetown | 22-10 | ||
| 11/19/2009 | L 54-74 | vs | Miami (FL) | 18-13 | C of Charleston Classic |
| 11/20/2009 | W 63-60 | vs | Penn State | 11-19 | C of Charleston Classic |
| 11/22/2009 | L 59-61 | vs | La Salle | 11-18 | C of Charleston Classic |
| 11/28/2009 | W 76-71 | George Mason | 17-13 | ||
| 11/30/2009 | W 82-55 | Alabama St | 13-14 | ||
| 12/2/2009 | L 50-51 | New Orleans | 5-22 | ||
| 12/6/2009 | L 48-62 | @ | Western Kentucky | 20-13 | |
| 12/16/2009 | L 57-61 | McNeese St | 6-20 | ||
| 12/19/2009 | L 77-78 | VCU | 20-9 | ||
| 12/21/2009 | W 73-70 | @ | UL Lafayette | 13-14 | |
| 12/30/2009 | W 78-54 | North Carolina A&T | 9-21 | ||
| 1/2/2010 | L 67-70 | @ | Lamar | 10-17 | |
| 1/6/2010 | L 59-73 | @ | Tulsa | 21-11 | |
| 1/9/2010 | L 49-58 | UAB | 22-7 | ||
| 1/13/2010 | W 72-58 | Rice | 7-21 | ||
| 1/16/2010 | L 79-89 | @ | Marshall | 18-9 | |
| 1/24/2010 | L 46-61 | East Carolina | 5-21 | ||
| 1/27/2010 | L 71-84 | @ | UTEP | 25-6 | |
| 1/30/2010 | L 40-58 | Southern Miss | 13-13 | ||
| 2/3/2010 | W 79-74 OT | @ | Rice | 7-21 | |
| 2/6/2010 | L 48-66 | SMU | 11-16 | ||
| 2/10/2010 | L 68-71 | @ | East Carolina | 5-21 | |
| 2/13/2010 | L 54-62 | @ | UCF | 12-17 | |
| 2/17/2010 | L 64-77 | Memphis | 21-10 | ||
| 2/20/2010 | L 55-58 | Marshall | 18-9 | ||
| 2/27/2010 | L 55-76 | @ | UAB | 22-7 | |
| 3/2/2010 | L 57-66 | @ | Southern Miss | 13-13 | |
| 3/6/2010 | L 48-66 | SMU | 11-16 | ||
| 3/10/2010 | L 47-57 | vs | Southern Miss | 13-13 | Conference USA |
| 7-23 | 330-334 |