| Date | Res | Opp | OW-OL | ||
| 11/17/2009 | W 96-66 | vs | Arkansas | 15-16 | Hall of Fame Classic |
| 11/21/2009 | W 69-56 | East Tenn St | 18-13 | Hall of Fame Classic | |
| 11/22/2009 | W 90-81 | Morgan St | 27-8 | Hall of Fame Classic | |
| 11/23/2009 | W 80-53 | Appalachian St | 20-10 | Hall of Fame Classic | |
| 11/28/2009 | L 71-76 | @ | UNLV | 23-8 | |
| 12/2/2009 | W 80-48 | Stetson | 5-22 | ||
| 12/5/2009 | L 65-87 | Charlotte | 19-12 | ||
| 12/12/2009 | L 83-91 | Western Carolina | 17-12 | ||
| 12/16/2009 | W 94-57 | Oral Roberts | 19-13 | ||
| 12/19/2009 | W 102-75 | Western Kentucky | 21-12 | ||
| 12/23/2009 | W 84-69 | UL Lafayette | 13-14 | ||
| 12/27/2009 | W 79-53 | Radford | 17-11 | ||
| 12/30/2009 | W 73-52 | South Florida | 19-11 | ||
| 1/2/2010 | L 62-71 | @ | Kentucky | 32-2 | |
| 1/6/2010 | W 92-70 | @ | Providence | 12-18 | |
| 1/9/2010 | W 75-68 | St. John's | 15-15 | ||
| 1/11/2010 | L 84-92 | Villanova | 23-7 | ||
| 1/16/2010 | L 77-82 OT | @ | Pittsburgh | 23-8 | |
| 1/21/2010 | L 77-80 | @ | Seton Hall | 17-13 | |
| 1/24/2010 | W 68-60 | Cincinnati | 17-13 | ||
| 1/30/2010 | L 74-77 | @ | West Virginia | 26-6 | |
| 2/1/2010 | W 82-69 | Connecticut | 18-12 | ||
| 2/6/2010 | W 76-60 | Rutgers | 14-15 | ||
| 2/11/2010 | L 55-74 | @ | St. John's | 15-15 | |
| 2/14/2010 | W 66-60 | @ | Syracuse | 28-2 | |
| 2/17/2010 | W 91-89 2 OT | Notre Dame | 22-10 | ||
| 2/20/2010 | W 68-59 | @ | DePaul | 8-22 | |
| 2/23/2010 | L 60-70 | Georgetown | 22-10 | ||
| 2/28/2010 | W 78-76 | @ | Connecticut | 18-12 | |
| 3/2/2010 | L 48-69 | @ | Marquette | 22-10 | |
| 3/6/2010 | W 76-60 | Rutgers | 14-15 | ||
| 3/10/2010 | L 66-69 | vs | Cincinnati | 17-13 | Big East |
| 20-12 | 532-325 |