| Date | Res | Opp | OW-OL | ||
| 11/9/2009 | W 75-43 | at | Albany | 7-24 | Coaches vs Cancer |
| 11/11/2009 | W 100-60 | at | Robert Morris | 24-10 | Coaches vs Cancer |
| 11/19/2009 | W 95-73 | vs | California | 23-9 | Coaches vs Cancer |
| 11/20/2009 | W 87-71 | vs | North Carolina | 16-14 | Coaches vs Cancer |
| 11/24/2009 | W 88-73 | Cornell | 25-3 | ||
| 11/27/2009 | W 85-60 | Columbia | 11-16 | ||
| 11/30/2009 | W 92-58 | Colgate | 10-18 | ||
| 12/5/2009 | W 101-55 | Maine | 19-9 | ||
| 12/10/2009 | W 85-73 | vs | Florida | 22-11 | |
| 12/13/2009 | W 75-51 | St. Francis (NY) | 12-17 | ||
| 12/19/2009 | W 85-72 | St. Bonaventure | 14-14 | ||
| 12/22/2009 | W 92-60 | Oakland | 24-7 | ||
| 12/29/2009 | W 80-73 | @ | Seton Hall | 18-12 | |
| 1/2/2010 | L 72-82 | Pittsburgh | 23-8 | ||
| 1/6/2010 | W 74-57 | Memphis | 22-9 | ||
| 1/10/2010 | W 82-65 | South Florida | 19-11 | ||
| 1/13/2010 | W 81-65 | @ | Rutgers | 14-16 | |
| 1/16/2010 | W 72-71 | @ | West Virginia | 27-5 | |
| 1/18/2010 | W 84-71 | @ | Notre Dame | 22-10 | |
| 1/23/2010 | W 76-71 | Marquette | 23-9 | ||
| 1/25/2010 | W 73-56 | Georgetown | 22-8 | ||
| 1/30/2010 | W 59-57 | @ | DePaul | 8-22 | |
| 2/2/2010 | W 85-68 | Providence | 12-17 | ||
| 2/7/2010 | W 71-54 | @ | Cincinnati | 18-13 | |
| 2/10/2010 | W 72-67 | Connecticut | 18-13 | ||
| 2/14/2010 | L 60-66 | Louisville | 19-12 | ||
| 2/18/2010 | W 75-71 | @ | Georgetown | 22-8 | |
| 2/23/2010 | W 99-85 | @ | Providence | 12-17 | |
| 2/27/2010 | W 95-77 | Villanova | 24-6 | ||
| 3/2/2010 | W 85-66 | St. John's | 16-15 | ||
| 3/11/2010 | L 84-91 | vs | Georgetown | 22-8 | Big East |
| 28-3 | 512-338 |