| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 96-62 | UNC Greensboro | 7-22 | ||
| 11/16/2009 | W 74-49 | Coastal Carolina | 25-4 | NIT Tipoff | |
| 11/17/2009 | W 101-59 | Charlotte | 20-11 | NIT Tipoff | |
| 11/21/2009 | W 104-67 | Radford | 17-11 | ||
| 11/25/2009 | W 64-53 | vs | Arizona St | 21-10 | NIT Tipoff |
| 11/27/2009 | W 68-59 | vs | Connecticut | 18-13 | NIT Tipoff |
| 12/2/2009 | L 69-73 | @ | Wisconsin | 23-8 | Big Ten-ACC Challenge |
| 12/5/2009 | W 80-71 | St. John's | 16-15 | ||
| 12/15/2009 | W 113-68 | Gardner Webb | 6-20 | ||
| 12/19/2009 | W 76-41 | vs | Gonzaga | 26-5 | |
| 12/29/2009 | W 84-63 | Long Beach | 15-15 | ||
| 12/31/2009 | W 114-55 | Pennsylvania | 6-21 | ||
| 1/3/2010 | W 74-53 | Clemson | 21-9 | ||
| 1/6/2010 | W 86-65 | vs | Iowa State | 15-16 | |
| 1/9/2010 | L 67-71 | @ | Georgia Tech | 21-9 | |
| 1/13/2010 | W 79-59 | Boston College | 15-14 | ||
| 1/17/2010 | W 90-70 | at | Wake Forest | 20-9 | |
| 1/20/2010 | L 74-88 | @ | North Carolina St | 18-16 | |
| 1/23/2010 | W 60-47 | @ | Clemson | 21-9 | |
| 1/27/2010 | W 70-56 | Florida St | 22-8 | ||
| 1/30/2010 | L 77-89 | @ | Georgetown | 22-10 | |
| 2/4/2010 | W 86-67 | Georgia Tech | 21-9 | ||
| 2/6/2010 | W 66-63 | @ | Boston College | 15-14 | |
| 2/10/2010 | W 64-54 | @ | North Carolina | 16-14 | |
| 2/13/2010 | W 77-56 | Maryland | 20-7 | ||
| 2/17/2010 | W 81-74 | @ | Miami (FL) | 19-11 | |
| 2/21/2010 | W 67-55 | Virginia Tech | 23-7 | ||
| 2/25/2010 | W 70-52 | Tulsa | 22-10 | ||
| 2/28/2010 | W 67-49 | @ | Virginia | 15-14 | |
| 3/3/2010 | L 72-79 | @ | Maryland | 20-7 | |
| 3/6/2010 | W 66-63 | @ | Boston College | 15-14 | |
| 3/12/2010 | W 57-46 | vs | Virginia | 15-14 | ACC |
| 3/13/2010 | W 77-74 | vs | Miami (FL) | 19-11 | ACC |
| 3/14/2010 | W 65-61 | vs | Georgia Tech | 21-9 | ACC |
| 29-5 | 469-309 |