| Date | Res | Opp | OW-OL | ||
| 11/15/2009 | W 83-60 | Loyola (Maryland) | 14-15 | ||
| 11/24/2009 | W 69-50 | vs | The Citadel | 14-14 | |
| 11/26/2009 | W 85-62 | vs | Long Beach | 15-15 | 76 Classic |
| 11/27/2009 | W 73-66 | vs | Texas A&M | 22-8 | 76 Classic |
| 11/29/2009 | W 84-66 | vs | Portland | 18-9 | 76 Classic |
| 12/9/2009 | W 68-39 | Duquesne | 15-14 | ||
| 12/12/2009 | W 69-43 | Coppin St | 5-22 | ||
| 12/19/2009 | W 80-78 | @ | Cleveland St | 15-15 | |
| 12/23/2009 | W 76-66 | Mississippi | 21-9 | ||
| 12/26/2009 | W 90-84 OT | at | Seton Hall | 18-11 | |
| 12/29/2009 | W 63-62 | Marquette | 23-9 | ||
| 1/1/2010 | L 62-77 | at | Purdue | 25-5 | |
| 1/6/2010 | W 86-52 | Rutgers | 14-16 | ||
| 1/9/2010 | L 68-70 | @ | Notre Dame | 21-10 | |
| 1/13/2010 | W 69-50 | @ | South Florida | 19-11 | |
| 1/16/2010 | L 71-72 | Syracuse | 27-3 | ||
| 1/20/2010 | W 86-60 | vs | Marshall | 20-8 | |
| 1/23/2010 | W 71-65 | Ohio State | 27-6 | ||
| 1/26/2010 | W 62-46 | @ | DePaul | 8-22 | |
| 1/30/2010 | W 77-74 | Louisville | 20-11 | ||
| 2/3/2010 | W 70-51 | Pittsburgh | 23-7 | ||
| 2/6/2010 | W 79-60 | @ | St. John's | 16-14 | |
| 2/8/2010 | L 75-82 | Villanova | 23-7 | ||
| 2/12/2010 | L 95-98 3 OT | @ | Pittsburgh | 23-7 | |
| 2/17/2010 | W 88-74 | @ | Providence | 12-18 | |
| 2/20/2010 | W 75-63 | Seton Hall | 18-11 | ||
| 2/22/2010 | L 62-73 | @ | Connecticut | 17-14 | |
| 2/27/2010 | W 74-68 | Cincinnati | 18-12 | ||
| 3/1/2010 | W 81-68 | Georgetown | 23-8 | ||
| 3/6/2010 | W 79-60 | @ | St. John's | 16-14 | |
| 3/11/2010 | W 54-51 | vs | Cincinnati | 18-12 | Big East |
| 3/12/2010 | W 53-51 | vs | Notre Dame | 21-10 | Big East |
| 3/13/2010 | W 60-58 | vs | Georgetown | 23-8 | Big East |
| 27-6 | 493-313 |