| Date | Res | Opp | OW-OL | ||
| 11/16/2009 | W 69-62 | Prairie View A&M | 13-12 | ||
| 11/18/2009 | W 92-68 | Toledo | 3-28 | ||
| 11/23/2009 | W 67-58 | vs | Vanderbilt | 23-7 | Maui Invitational |
| 11/24/2009 | W 69-57 | vs | Maryland | 21-7 | Maui Invitational |
| 11/25/2009 | L 59-61 OT | vs | Gonzaga | 25-6 | Maui Invitational |
| 12/1/2009 | W 94-57 | Texas Southern | 14-16 | ||
| 12/10/2009 | W 63-59 | Miami-Ohio | 15-17 | ||
| 12/13/2009 | L 79-83 2 OT | @ | Xavier | 22-9 | |
| 12/16/2009 | L 47-64 | @ | UAB | 23-7 | |
| 12/19/2009 | W 80-52 | Lipscomb | 16-13 | ||
| 12/22/2009 | W 74-57 | Winthrop | 17-12 | ||
| 12/30/2009 | W 71-69 | Connecticut | 18-12 | ||
| 1/2/2010 | W 65-58 | @ | Rutgers | 14-15 | |
| 1/4/2010 | L 71-74 | Pittsburgh | 23-8 | ||
| 1/6/2010 | W 87-58 | CS Bakersfield | 7-22 | ||
| 1/9/2010 | L 76-83 | @ | Seton Hall | 17-13 | |
| 1/13/2010 | L 50-52 | @ | St. John's | 15-16 | |
| 1/16/2010 | W 60-58 | Notre Dame | 21-10 | ||
| 1/20/2010 | W 78-70 | South Florida | 18-11 | ||
| 1/24/2010 | L 60-68 | @ | Louisville | 19-11 | |
| 1/30/2010 | W 92-88 | Providence | 12-18 | ||
| 2/4/2010 | L 65-83 | @ | Notre Dame | 21-10 | |
| 2/7/2010 | L 54-71 | Syracuse | 27-3 | ||
| 2/13/2010 | W 60-48 | @ | Connecticut | 18-12 | |
| 2/16/2010 | L 57-65 | @ | South Florida | 18-11 | |
| 2/21/2010 | L 76-79 OT | Marquette | 22-10 | ||
| 2/24/2010 | W 74-69 | DePaul | 8-22 | ||
| 2/27/2010 | L 68-74 | @ | West Virginia | 25-6 | |
| 3/2/2010 | L 73-77 | Villanova | 23-7 | ||
| 3/9/2010 | W 69-68 | vs | Rutgers | 14-15 | Big East |
| 3/10/2010 | W 69-66 | vs | Louisville | 19-11 | Big East |
| 3/11/2010 | L 51-54 | vs | West Virginia | 25-6 | Big East |
| 18-14 | 461-318 |