| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 83-57 | Youngstown St | 6-22 | ||
| 11/17/2009 | W 101-57 | Bowling Green | 13-16 | ||
| 11/21/2009 | W 105-65 | Sacred Heart | 14-15 | ||
| 11/26/2009 | L 61-71 | vs | Marquette | 22-10 | Old Spice Classic |
| 11/27/2009 | W 80-67 | vs | Creighton | 16-14 | Old Spice Classic |
| 11/29/2009 | L 64-69 | vs | Baylor | 22-8 | Old Spice Classic |
| 12/4/2009 | W 77-61 | Kent St | 22-8 | ||
| 12/8/2009 | L 56-71 | @ | Kansas St | 24-7 | |
| 12/13/2009 | W 83-79 2 OT | Cincinnati | 18-13 | ||
| 12/19/2009 | L 68-69 | @ | Butler | 27-4 | |
| 12/23/2009 | W 70-67 | Miami-Ohio | 15-17 | ||
| 12/29/2009 | W 89-65 | LSU | 10-20 | ||
| 1/3/2010 | L 92-96 2 OT | @ | Wake Forest | 19-10 | |
| 1/7/2010 | W 68-62 | @ | La Salle | 12-17 | |
| 1/10/2010 | W 76-69 | @ | George Washington | 16-13 | |
| 1/13/2010 | W 86-74 | Charlotte | 20-10 | ||
| 1/16/2010 | W 78-74 | Dayton | 19-9 | ||
| 1/20/2010 | L 72-77 | @ | Temple | 27-5 | |
| 1/23/2010 | W 72-61 | Rhode Island | 24-7 | ||
| 1/28/2010 | W 86-50 | Duquesne | 15-14 | ||
| 1/31/2010 | W 108-60 | Fordham | 2-24 | ||
| 2/3/2010 | W 87-79 | @ | Massachusetts | 10-20 | |
| 2/6/2010 | L 65-90 | @ | Dayton | 19-9 | |
| 2/13/2010 | W 76-64 | @ | Florida | 22-11 | |
| 2/17/2010 | W 88-52 | Saint Joseph's | 10-19 | ||
| 2/20/2010 | W 81-67 | @ | Charlotte | 20-10 | |
| 2/24/2010 | W 73-71 | @ | Saint Louis | 19-10 | |
| 2/28/2010 | W 78-76 2 OT | Richmond | 25-7 | ||
| 3/3/2010 | W 82-56 | @ | Fordham | 2-24 | |
| 3/6/2010 | L 65-90 | @ | Dayton | 19-9 | |
| 3/12/2010 | W 78-73 | vs | Dayton | 19-9 | Atlantic 10 |
| 3/13/2010 | L 85-89 OT | vs | Richmond | 25-7 | Atlantic 10 |
| 23-9 | 449-330 |