| Date | Res | Opp | OW-OL | ||
| 11/9/2009 | W 88-72 | at | Florida Intl | 6-24 | Coaches vs Cancer |
| 11/11/2009 | W 89-42 | at | NCCU | 4-21 | Coaches vs Cancer |
| 11/15/2009 | W 88-77 | Valparaiso | 13-16 | ||
| 11/19/2009 | W 77-73 | vs | Ohio State | 27-6 | Coaches vs Cancer |
| 11/20/2009 | L 71-87 | vs | Syracuse | 27-3 | Coaches vs Cancer |
| 11/23/2009 | W 93-72 | Gardner Webb | 6-20 | ||
| 11/29/2009 | W 80-73 | Nevada | 18-12 | ||
| 12/1/2009 | W 89-82 | Michigan St | 24-8 | Big Ten-ACC Challenge | |
| 12/5/2009 | L 66-68 | @ | Kentucky | 32-2 | |
| 12/12/2009 | W 103-64 | Presbyterian | 4-26 | ||
| 12/19/2009 | L 90-103 | vs | Texas | 23-9 | |
| 12/22/2009 | W 98-61 | Marshall | 20-8 | ||
| 12/28/2009 | W 81-67 | Rutgers | 14-16 | ||
| 12/30/2009 | W 87-70 | Albany | 7-24 | ||
| 1/4/2010 | L 79-82 OT | @ | Coll of Charleston | 20-11 | |
| 1/10/2010 | W 78-64 | Virginia Tech | 22-7 | ||
| 1/13/2010 | L 64-83 | @ | Clemson | 20-11 | |
| 1/16/2010 | L 71-73 | Georgia Tech | 19-11 | ||
| 1/20/2010 | L 69-82 | Wake Forest | 19-9 | ||
| 1/26/2010 | W 77-63 | @ | North Carolina St | 19-14 | |
| 1/31/2010 | L 60-75 | Virginia | 14-16 | ||
| 2/4/2010 | L 70-74 | @ | Virginia Tech | 22-7 | |
| 2/7/2010 | L 71-92 | @ | Maryland | 20-8 | |
| 2/10/2010 | L 54-64 | Duke | 28-5 | ||
| 2/13/2010 | W 74-61 | North Carolina St | 19-14 | ||
| 2/16/2010 | L 51-68 | @ | Georgia Tech | 19-11 | |
| 2/20/2010 | L 67-71 | @ | Boston College | 14-17 | |
| 2/24/2010 | L 67-77 | Florida St | 21-9 | ||
| 2/27/2010 | W 77-68 | @ | Wake Forest | 19-9 | |
| 3/2/2010 | W 69-62 | Miami (FL) | 19-12 | ||
| 3/11/2010 | L 58-62 | vs | Georgia Tech | 19-11 | ACC |
| 16-15 | 460-325 |