| Date | Res | Opp | OW-OL | ||
| 11/11/2009 | L 42-89 | at | North Carolina | 15-15 | Coaches vs Cancer |
| 11/14/2009 | L 53-83 | @ | Miami (FL) | 18-13 | |
| 11/20/2009 | L 74-83 | @ | Florida Intl | 5-25 | Coaches vs Cancer |
| 11/22/2009 | L 61-84 | vs | Murray St | 26-4 | Coaches vs Cancer |
| 11/23/2009 | L 66-79 | vs | James Madison | 11-19 | Coaches vs Cancer |
| 11/28/2009 | L 63-73 | @ | Iowa | 9-22 | |
| 12/2/2009 | L 49-61 | @ | Air Force | 7-21 | |
| 12/16/2009 | L 67-76 | Florida Gulf Coast | 7-22 | ||
| 12/19/2009 | L 58-81 | @ | Indiana | 8-21 | |
| 12/21/2009 | L 45-59 | @ | Ball State | 13-16 | |
| 12/29/2009 | L 58-70 | @ | High Point | 11-15 | |
| 1/3/2010 | L 58-68 | @ | East Carolina | 6-21 | |
| 1/6/2010 | L 54-75 | @ | Colgate | 9-19 | |
| 1/9/2010 | L 50-78 | @ | SMU | 12-16 | |
| 1/11/2010 | L 55-58 | High Point | 11-15 | ||
| 1/18/2010 | L 30-72 | @ | Virginia Tech | 22-8 | |
| 1/20/2010 | L 44-46 OT | @ | Savannah St | 6-14 | |
| 1/27/2010 | L 57-70 | @ | Youngstown St | 5-23 | |
| 1/30/2010 | L 42-77 | @ | North Carolina St | 18-16 | |
| 2/2/2010 | L 50-53 | Western Illinois | 9-17 | ||
| 2/6/2010 | W 65-60 | Savannah St | 6-14 | ||
| 2/10/2010 | W 73-71 | UM Eastern Shore | 11-21 | ||
| 2/13/2010 | W 81-78 | Longwood | 8-18 | ||
| 2/15/2010 | L 57-68 | Coastal Carolina | 24-5 | ||
| 2/25/2010 | L 69-83 | @ | Longwood | 8-18 | |
| 3/6/2010 | W 65-60 | Savannah St | 6-14 | ||
| 4-22 | 260-371 |