| Date | Res | Opp | OW-OL | ||
| 11/16/2009 | W 87-61 | Jacksonville | 19-11 | ||
| 11/18/2009 | W 80-38 | Stetson | 5-22 | ||
| 11/21/2009 | W 89-50 | @ | Mercer | 13-15 | |
| 11/24/2009 | L 52-68 | @ | Florida | 21-12 | |
| 11/26/2009 | W 54-49 | vs | Iona | 21-9 | Old Spice Classic |
| 11/27/2009 | W 60-51 | vs | Alabama | 16-15 | Old Spice Classic |
| 11/29/2009 | W 57-56 | vs | Marquette | 23-9 | Old Spice Classic |
| 12/2/2009 | L 64-77 | @ | Ohio State | 26-7 | Big Ten-ACC Challenge |
| 12/6/2009 | W 82-62 | Florida Intl | 6-24 | ||
| 12/15/2009 | W 62-55 | Georgia St | 11-19 | ||
| 12/17/2009 | W 76-72 | Auburn | 14-16 | ||
| 12/20/2009 | W 66-59 OT | @ | Georgia Tech | 22-9 | |
| 12/22/2009 | W 95-68 | UT Martin | 2-25 | ||
| 12/31/2009 | W 81-34 | Alabama A&M | 7-15 | ||
| 1/4/2010 | W 94-54 | Texas A&M CC | 14-14 | ||
| 1/10/2010 | L 68-77 | @ | Maryland | 19-8 | |
| 1/12/2010 | L 81-88 | North Carolina St | 17-16 | ||
| 1/16/2010 | W 63-58 | Virginia Tech | 23-7 | ||
| 1/24/2010 | W 68-66 | Georgia Tech | 22-9 | ||
| 1/27/2010 | L 56-70 | @ | Duke | 28-5 | |
| 1/30/2010 | W 61-57 | @ | Boston College | 15-15 | |
| 2/4/2010 | L 67-71 | Maryland | 19-8 | ||
| 2/6/2010 | W 71-65 | Miami (FL) | 19-11 | ||
| 2/10/2010 | L 67-77 | @ | Clemson | 19-11 | |
| 2/14/2010 | W 62-47 | Boston College | 15-15 | ||
| 2/17/2010 | W 69-50 | @ | Virginia | 15-15 | |
| 2/24/2010 | W 77-67 | @ | North Carolina | 16-14 | |
| 2/28/2010 | L 50-53 | Clemson | 19-11 | ||
| 3/3/2010 | W 51-47 | Wake Forest | 20-9 | ||
| 3/6/2010 | W 71-65 | Miami (FL) | 19-11 | ||
| 3/12/2010 | L 52-58 | vs | North Carolina St | 17-16 | ACC |
| 22-9 | 411-333 |