| Date | Res | Opp | OW-OL | ||
| 11/14/2009 | W 83-53 | NCCU | 4-21 | ||
| 11/19/2009 | W 74-54 | vs | Tulane | 7-22 | C of Charleston Classic |
| 11/20/2009 | W 67-60 | vs | UNC Wilmington | 9-20 | C of Charleston Classic |
| 11/22/2009 | W 85-70 | vs | South Carolina | 14-16 | C of Charleston Classic |
| 11/25/2009 | W 77-58 | Florida Gulf Coast | 8-21 | ||
| 11/28/2009 | W 70-41 | SC Upstate | 7-22 | ||
| 12/2/2009 | W 63-58 | Minnesota | 22-12 | Big Ten-ACC Challenge | |
| 12/6/2009 | L 60-61 | @ | Boston College | 13-17 | |
| 12/12/2009 | W 91-54 | South Carolina St | 16-13 | ||
| 12/16/2009 | W 69-49 | @ | Stetson | 5-22 | |
| 12/19/2009 | W 87-69 | vs | Florida Atlantic | 12-15 | |
| 12/21/2009 | W 80-59 | North Carolina A&T | 9-21 | ||
| 12/30/2009 | W 73-55 | Bethune Cookman | 15-15 | ||
| 1/3/2010 | W 86-63 | @ | Pepperdine | 6-22 | |
| 1/9/2010 | W 67-66 | Wake Forest | 19-8 | ||
| 1/13/2010 | L 66-81 | @ | Virginia Tech | 22-6 | |
| 1/16/2010 | L 57-75 | @ | Virginia | 14-15 | |
| 1/19/2010 | L 75-79 | Boston College | 13-17 | ||
| 1/26/2010 | L 59-81 | @ | Maryland | 20-8 | |
| 1/31/2010 | W 82-75 | Virginia Tech | 22-6 | ||
| 2/2/2010 | L 53-62 | @ | Wake Forest | 19-8 | |
| 2/6/2010 | L 65-71 | @ | Florida St | 20-9 | |
| 2/10/2010 | W 64-62 | Georgia Tech | 22-10 | ||
| 2/13/2010 | L 66-74 | @ | Clemson | 20-11 | |
| 2/17/2010 | L 74-81 | Duke | 27-5 | ||
| 2/23/2010 | W 74-62 | Virginia | 14-15 | ||
| 2/27/2010 | L 66-71 | North Carolina St | 18-16 | ||
| 3/2/2010 | L 62-69 | @ | North Carolina | 15-15 | |
| 3/6/2010 | L 65-71 | @ | Florida St | 20-9 | |
| 3/11/2010 | W 83-62 | vs | Wake Forest | 19-8 | ACC |
| 3/12/2010 | W 70-65 | vs | Virginia Tech | 22-6 | ACC |
| 3/13/2010 | L 74-77 | vs | Duke | 27-5 | ACC |
| 19-13 | 344-362 |