| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 85-72 | Longwood | 9-18 | ||
| 11/16/2009 | L 49-66 | @ | South Florida | 18-12 | |
| 11/19/2009 | W 79-46 | Rider | 16-16 | Cancun Tournament | |
| 11/21/2009 | W 76-55 | Oral Roberts | 19-13 | Cancun Tournament | |
| 11/24/2009 | L 52-57 | vs | Stanford | 13-18 | Cancun Tournament |
| 11/25/2009 | W 76-65 | vs | Cleveland St | 15-15 | Cancun Tournament |
| 11/30/2009 | L 66-69 | Penn State | 10-20 | Big Ten-ACC Challenge | |
| 12/7/2009 | L 67-68 | @ | Auburn | 13-17 | |
| 12/21/2009 | W 68-37 | NJIT | 7-20 | ||
| 12/23/2009 | W 80-54 | Hampton | 14-18 | ||
| 12/30/2009 | W 72-63 | UAB | 24-6 | ||
| 1/5/2010 | W 72-53 | UT Pan American | 5-27 | ||
| 1/9/2010 | W 70-62 | @ | North Carolina St | 19-14 | |
| 1/13/2010 | W 82-75 | Georgia Tech | 22-10 | ||
| 1/16/2010 | W 75-57 | Miami (FL) | 18-12 | ||
| 1/18/2010 | W 69-67 | UNC Wilmington | 9-20 | ||
| 1/23/2010 | L 57-69 | @ | Wake Forest | 17-10 | |
| 1/28/2010 | L 71-76 OT | Virginia Tech | 21-8 | ||
| 1/31/2010 | W 75-60 | @ | North Carolina | 16-14 | |
| 2/3/2010 | W 59-47 | North Carolina St | 19-14 | ||
| 2/6/2010 | L 61-64 OT | Wake Forest | 17-10 | ||
| 2/13/2010 | L 55-61 | @ | Virginia Tech | 21-8 | |
| 2/15/2010 | L 66-85 | @ | Maryland | 20-8 | |
| 2/17/2010 | L 50-69 | Florida St | 21-9 | ||
| 2/20/2010 | L 49-72 | @ | Clemson | 20-11 | |
| 2/23/2010 | L 62-74 | @ | Miami (FL) | 18-12 | |
| 2/28/2010 | L 49-67 | Duke | 27-5 | ||
| 3/3/2010 | L 55-68 | @ | Boston College | 14-16 | |
| 3/6/2010 | L 61-64 OT | Wake Forest | 17-10 | ||
| 3/11/2010 | W 68-62 | vs | Boston College | 14-16 | ACC |
| 3/12/2010 | L 46-57 | vs | Duke | 27-5 | ACC |
| 15-16 | 387-337 |