| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 76-56 | Oral Roberts | 19-13 | ||
| 11/15/2009 | W 89-58 | @ | East Carolina | 7-20 | |
| 11/18/2009 | W 83-60 | High Point | 13-14 | ||
| 11/24/2009 | W 76-52 | Winston Salem St | 9-16 | ||
| 11/28/2009 | L 68-78 | William & Mary | 20-10 | ||
| 12/1/2009 | L 58-69 | @ | Purdue | 25-5 | Big Ten-ACC Challenge |
| 12/5/2009 | W 77-75 | @ | Gonzaga | 26-5 | |
| 12/13/2009 | W 90-50 | Elon | 8-21 | ||
| 12/16/2009 | W 80-69 | @ | UNC Wilmington | 9-20 | |
| 12/20/2009 | W 67-59 | North Carolina St | 18-15 | ||
| 12/28/2009 | W 75-60 | @ | UNC Greensboro | 7-22 | |
| 12/31/2009 | W 74-68 OT | Richmond | 26-7 | ||
| 1/3/2010 | W 96-92 2 OT | Xavier | 23-8 | ||
| 1/9/2010 | L 66-67 | @ | Miami (FL) | 17-12 | |
| 1/12/2010 | W 85-83 OT | Maryland | 21-7 | ||
| 1/17/2010 | L 70-90 | at | Duke | 28-5 | |
| 1/20/2010 | W 82-69 | @ | North Carolina | 15-14 | |
| 1/23/2010 | W 69-57 | Virginia | 15-13 | ||
| 1/28/2010 | L 58-79 | @ | Georgia Tech | 21-10 | |
| 2/2/2010 | W 62-53 | Miami (FL) | 17-12 | ||
| 2/6/2010 | W 64-61 OT | @ | Virginia | 15-13 | |
| 2/9/2010 | W 92-85 | Boston College | 15-16 | ||
| 2/13/2010 | W 75-64 | Georgia Tech | 21-10 | ||
| 2/16/2010 | L 83-87 | @ | Virginia Tech | 22-8 | |
| 2/20/2010 | L 54-68 | @ | North Carolina St | 18-15 | |
| 2/27/2010 | L 68-77 | North Carolina | 15-14 | ||
| 3/3/2010 | L 47-51 | @ | Florida St | 21-9 | |
| 3/6/2010 | W 64-61 OT | @ | Virginia | 15-13 | |
| 3/7/2010 | W 70-65 | Clemson | 21-10 | ||
| 3/11/2010 | L 62-83 | vs | Miami (FL) | 17-12 | ACC |
| 20-10 | 406-280 |