| Date | Res | Opp | OW-OL | ||
| 11/12/2009 | W 69-53 | at | Georgia St | 11-19 | Glenn Wilkes Classic |
| 11/20/2009 | W 66-45 | vs | Akron | 24-8 | Glenn Wilkes Classic |
| 11/21/2009 | W 66-59 | vs | Austin Peay | 15-15 | Glenn Wilkes Classic |
| 11/22/2009 | W 60-58 | vs | Auburn | 14-16 | Glenn Wilkes Classic |
| 11/29/2009 | W 69-52 | New Orleans | 6-21 | ||
| 12/1/2009 | L 53-65 | Northwestern | 19-12 | Big Ten-ACC Challenge | |
| 12/5/2009 | W 77-73 | @ | Marquette | 23-9 | |
| 12/12/2009 | W 75-57 | Georgia So | 7-22 | ||
| 12/17/2009 | W 79-76 | Elon | 8-21 | ||
| 12/20/2009 | L 59-67 | @ | Wake Forest | 19-9 | |
| 12/23/2009 | L 74-76 | @ | Arizona | 14-16 | |
| 12/29/2009 | W 68-52 | Winthrop | 17-12 | ||
| 12/31/2009 | W 89-67 | @ | UNC Greensboro | 7-22 | |
| 1/3/2010 | L 61-62 OT | Florida | 21-12 | ||
| 1/6/2010 | W 87-70 | Holy Cross | 10-21 | ||
| 1/9/2010 | L 62-70 | Virginia | 13-16 | ||
| 1/12/2010 | W 88-81 | @ | Florida St | 22-7 | |
| 1/16/2010 | L 70-73 | Clemson | 20-10 | ||
| 1/20/2010 | W 88-74 | Duke | 29-4 | ||
| 1/23/2010 | L 64-88 | @ | Maryland | 19-8 | |
| 1/26/2010 | L 63-77 | North Carolina | 14-15 | ||
| 1/30/2010 | W 77-42 | NCCU | 4-21 | ||
| 2/3/2010 | L 47-59 | @ | Virginia | 13-16 | |
| 2/6/2010 | L 71-73 | @ | Georgia Tech | 19-11 | |
| 2/10/2010 | L 52-72 | Virginia Tech | 21-8 | ||
| 2/13/2010 | L 61-74 | @ | North Carolina | 14-15 | |
| 2/17/2010 | L 58-67 | Maryland | 19-8 | ||
| 2/20/2010 | W 68-54 | Wake Forest | 19-9 | ||
| 2/27/2010 | W 71-66 | @ | Miami (FL) | 19-12 | |
| 3/3/2010 | L 59-71 | @ | Virginia Tech | 21-8 | |
| 3/6/2010 | L 71-73 | @ | Georgia Tech | 19-11 | |
| 3/7/2010 | W 66-54 | Boston College | 15-16 | ||
| 3/11/2010 | W 59-57 | vs | Clemson | 20-10 | ACC |
| 3/12/2010 | W 58-52 | vs | Florida St | 22-7 | ACC |
| 3/13/2010 | L 54-57 | vs | Georgia Tech | 19-11 | ACC |
| 19-16 | 410-363 |