| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 89-58 | Dartmouth | 4-22 | ||
| 11/17/2009 | W 72-44 | St. Francis (NY) | 12-17 | ||
| 11/20/2009 | L 80-84 | vs | Saint Joseph's | 9-20 | Paradise Jam |
| 11/21/2009 | W 75-58 | vs | South Dakota St | 13-15 | Paradise Jam |
| 11/23/2009 | L 69-81 | vs | Northern Iowa | 26-4 | Paradise Jam |
| 11/28/2009 | W 82-77 | @ | Providence | 12-18 | |
| 12/2/2009 | W 62-58 | @ | Michigan | 14-17 | Big Ten-ACC Challenge |
| 12/6/2009 | W 61-60 | Miami (FL) | 19-11 | ||
| 12/9/2009 | L 67-74 | Harvard | 19-7 | ||
| 12/13/2009 | L 69-80 | Rhode Island | 23-8 | ||
| 12/20/2009 | W 72-46 | Bryant | 1-29 | ||
| 12/23/2009 | W 79-67 | Massachusetts | 10-20 | ||
| 12/30/2009 | W 85-76 | South Carolina | 14-16 | ||
| 1/2/2010 | L 51-52 | Maine | 18-10 | ||
| 1/5/2010 | W 89-32 | NJIT | 7-20 | ||
| 1/9/2010 | L 56-72 | @ | Clemson | 20-10 | |
| 1/13/2010 | L 59-79 | @ | Duke | 26-5 | |
| 1/16/2010 | L 57-73 | Maryland | 20-8 | ||
| 1/19/2010 | W 79-75 | @ | Miami (FL) | 19-11 | |
| 1/23/2010 | L 62-63 | @ | Virginia Tech | 22-7 | |
| 1/26/2010 | W 75-69 | Clemson | 20-10 | ||
| 1/30/2010 | L 57-61 | Florida St | 20-9 | ||
| 2/6/2010 | L 63-66 | Duke | 26-5 | ||
| 2/9/2010 | L 85-92 | @ | Wake Forest | 19-10 | |
| 2/14/2010 | L 47-62 | @ | Florida St | 20-9 | |
| 2/20/2010 | W 71-67 | North Carolina | 16-14 | ||
| 2/24/2010 | W 80-60 | Virginia Tech | 22-7 | ||
| 2/27/2010 | L 66-73 | @ | Georgia Tech | 21-11 | |
| 3/3/2010 | W 68-55 | Virginia | 14-15 | ||
| 3/6/2010 | L 63-66 | Duke | 26-5 | ||
| 3/7/2010 | L 54-66 | @ | North Carolina St | 18-16 | |
| 3/11/2010 | L 62-68 | vs | Virginia | 14-15 | ACC |
| 15-17 | 397-339 |