| Date | Res | Opp | OW-OL | ||
| 11/9/2009 | W 100-60 | at | Alcorn St | 1-29 | Coaches vs Cancer |
| 11/12/2009 | W 72-44 | at | James Madison | 12-18 | Coaches vs Cancer |
| 11/19/2009 | L 73-77 | vs | North Carolina | 15-15 | Coaches vs Cancer |
| 11/20/2009 | W 76-70 | vs | California | 23-9 | Coaches vs Cancer |
| 11/24/2009 | W 84-64 | Lipscomb | 16-13 | ||
| 11/28/2009 | W 110-47 | St. Francis (PA) | 11-19 | ||
| 12/2/2009 | W 77-64 | Florida St | 22-8 | Big Ten-ACC Challenge | |
| 12/5/2009 | W 111-60 | Eastern Michigan | 16-14 | ||
| 12/12/2009 | L 66-74 | @ | Butler | 27-4 | |
| 12/16/2009 | W 78-48 | Presbyterian | 4-26 | ||
| 12/19/2009 | W 60-44 | Delaware St | 14-12 | ||
| 12/22/2009 | W 72-59 | Cleveland St | 15-15 | ||
| 12/31/2009 | L 43-65 | @ | Wisconsin | 23-7 | |
| 1/3/2010 | L 64-73 | @ | Michigan | 13-16 | |
| 1/6/2010 | W 79-54 | Indiana | 9-19 | ||
| 1/9/2010 | L 62-73 | @ | Minnesota | 21-11 | |
| 1/12/2010 | W 70-66 | @ | Purdue | 25-4 | |
| 1/16/2010 | W 60-51 | Wisconsin | 23-7 | ||
| 1/19/2010 | W 76-56 | Northwestern | 20-11 | ||
| 1/23/2010 | L 65-71 | @ | West Virginia | 26-6 | |
| 1/27/2010 | W 65-57 | @ | Iowa | 10-20 | |
| 1/31/2010 | W 85-63 | Minnesota | 21-11 | ||
| 2/3/2010 | W 75-62 | Penn State | 11-18 | ||
| 2/7/2010 | W 68-58 | Iowa | 10-20 | ||
| 2/10/2010 | W 69-52 | @ | Indiana | 9-19 | |
| 2/14/2010 | W 72-53 | @ | Illinois | 20-11 | |
| 2/17/2010 | L 57-60 | Purdue | 25-4 | ||
| 2/21/2010 | W 74-67 | @ | Michigan St | 24-8 | |
| 2/24/2010 | W 75-67 | @ | Penn State | 11-18 | |
| 2/27/2010 | W 66-55 | Michigan | 13-16 | ||
| 3/2/2010 | W 73-57 | Illinois | 20-11 | ||
| 3/12/2010 | W 69-68 | vs | Michigan | 13-16 | Big Ten |
| 3/13/2010 | W 88-81 2 OT | vs | Illinois | 20-11 | Big Ten |
| 3/14/2010 | W 90-61 | vs | Minnesota | 21-11 | Big Ten |
| 27-7 | 378-313 |