| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 87-50 | Tennessee Tech | 13-16 | ||
| 11/16/2009 | W 82-42 | Stephen F. Austin | 20-8 | ||
| 11/19/2009 | W 76-51 | Utah Valley | 9-16 | ||
| 11/26/2009 | W 82-73 | vs | Butler | 28-3 | 76 Classic |
| 11/27/2009 | L 56-61 | vs | Portland | 17-10 | 76 Classic |
| 11/29/2009 | L 65-66 | vs | Texas A&M | 21-9 | 76 Classic |
| 12/2/2009 | L 58-63 | @ | Miami (FL) | 18-13 | Big Ten-ACC Challenge |
| 12/5/2009 | W 91-55 | Brown | 9-19 | ||
| 12/8/2009 | W 94-64 | Morgan St | 27-8 | ||
| 12/12/2009 | W 97-74 | Saint Joseph's | 10-19 | ||
| 12/15/2009 | W 89-48 | Northern Illinois | 10-20 | ||
| 12/23/2009 | W 92-62 | South Dakota St | 13-15 | ||
| 12/29/2009 | W 75-70 | Penn State | 11-16 | ||
| 1/2/2010 | W 86-74 | @ | Iowa | 10-20 | |
| 1/5/2010 | L 60-79 | @ | Purdue | 24-4 | |
| 1/9/2010 | W 73-62 | Ohio State | 25-6 | ||
| 1/13/2010 | L 53-60 | @ | Michigan St | 22-8 | |
| 1/17/2010 | L 78-81 OT | at | Indiana | 8-20 | |
| 1/23/2010 | L 64-65 | Michigan St | 22-8 | ||
| 1/26/2010 | W 65-61 | Northwestern | 19-11 | ||
| 1/31/2010 | L 63-85 | @ | Ohio State | 25-6 | |
| 2/6/2010 | W 66-64 | @ | Penn State | 11-16 | |
| 2/11/2010 | L 63-71 | Michigan | 12-18 | ||
| 2/14/2010 | L 74-77 OT | @ | Northwestern | 19-11 | |
| 2/18/2010 | W 68-52 | Wisconsin | 24-7 | ||
| 2/20/2010 | W 81-58 | Indiana | 8-20 | ||
| 2/24/2010 | L 58-59 | Purdue | 24-4 | ||
| 2/27/2010 | W 62-60 | @ | Illinois | 20-13 | |
| 3/2/2010 | L 55-83 | @ | Michigan | 12-18 | |
| 3/6/2010 | W 66-64 | @ | Penn State | 11-16 | |
| 3/7/2010 | W 88-53 | Iowa | 10-20 | ||
| 3/11/2010 | W 76-55 | vs | Penn State | 11-16 | Big Ten |
| 3/12/2010 | W 72-67 OT | vs | Michigan St | 22-8 | Big Ten |
| 3/13/2010 | W 69-42 | vs | Purdue | 24-4 | Big Ten |
| 3/14/2010 | L 61-90 | vs | Ohio State | 25-6 | Big Ten |
| 22-13 | 370-279 |