| Date | Res | Opp | OW-OL | ||
| 11/15/2009 | L 50-62 | UT San Antonio | 15-11 | CBE Classic | |
| 11/17/2009 | L 50-52 | Duquesne | 14-15 | CBE Classic | |
| 11/20/2009 | W 68-46 | Bowling Green | 13-16 | ||
| 11/23/2009 | L 60-85 | vs | Texas | 23-9 | CBE Classic |
| 11/24/2009 | L 57-74 | vs | Wichita St | 22-9 | CBE Classic |
| 11/28/2009 | W 73-63 | NCCU | 4-21 | ||
| 12/1/2009 | L 64-70 | Virginia Tech | 22-8 | Big Ten-ACC Challenge | |
| 12/5/2009 | W 80-51 | Prairie View A&M | 13-12 | ||
| 12/8/2009 | L 50-67 | @ | Northern Iowa | 26-4 | |
| 12/11/2009 | L 71-81 | @ | Iowa State | 14-17 | |
| 12/19/2009 | W 71-67 | Drake | 14-18 | ||
| 12/21/2009 | W 82-69 | South Carolina St | 16-13 | ||
| 12/29/2009 | L 56-67 | Purdue | 24-5 | ||
| 1/2/2010 | L 74-86 | Minnesota | 20-13 | ||
| 1/5/2010 | L 42-59 | @ | Illinois | 18-14 | |
| 1/9/2010 | L 53-71 | Michigan St | 22-9 | ||
| 1/12/2010 | W 67-62 | Tennessee St | 10-22 | ||
| 1/16/2010 | W 67-64 | Penn State | 11-19 | ||
| 1/20/2010 | L 63-70 | @ | Michigan St | 22-9 | |
| 1/24/2010 | W 58-43 | @ | Indiana | 9-19 | |
| 1/27/2010 | L 57-65 | Ohio State | 25-7 | ||
| 1/30/2010 | L 46-60 | @ | Michigan | 11-18 | |
| 2/3/2010 | L 49-57 | Illinois | 18-14 | ||
| 2/7/2010 | L 58-68 | @ | Ohio State | 25-7 | |
| 2/10/2010 | W 78-65 | Northwestern | 19-11 | ||
| 2/13/2010 | L 40-63 | @ | Purdue | 24-5 | |
| 2/16/2010 | L 78-80 OT | Michigan | 11-18 | ||
| 2/25/2010 | L 57-74 | @ | Northwestern | 19-11 | |
| 2/28/2010 | W 73-57 | Indiana | 9-19 | ||
| 3/3/2010 | L 40-67 | @ | Wisconsin | 23-8 | |
| 3/7/2010 | L 53-88 | @ | Minnesota | 20-13 | |
| 3/11/2010 | L 52-59 | vs | Michigan | 11-18 | Big Ten |
| 10-22 | 388-298 |