| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 83-60 | Howard | 7-25 | ||
| 11/16/2009 | W 69-61 | SC Upstate | 7-22 | ||
| 11/19/2009 | L 71-89 | vs | Mississippi | 20-10 | Puerto Rico Shootout |
| 11/20/2009 | L 67-71 | vs | Boston U | 18-13 | Puerto Rico Shootout |
| 11/22/2009 | L 66-69 | vs | George Mason | 16-14 | Puerto Rico Shootout |
| 11/28/2009 | W 90-72 | Northwestern St | 7-17 | ||
| 12/1/2009 | L 68-80 | Maryland | 20-8 | Big Ten-ACC Challenge | |
| 12/8/2009 | W 74-64 | vs | Pittsburgh | 24-7 | |
| 12/12/2009 | L 73-90 | Kentucky | 32-2 | ||
| 12/19/2009 | W 81-58 | NCCU | 4-21 | ||
| 12/22/2009 | L 67-72 | Loyola (Maryland) | 13-16 | ||
| 12/28/2009 | W 90-42 | Bryant | 1-29 | ||
| 12/31/2009 | W 71-65 | Michigan | 13-17 | ||
| 1/6/2010 | L 54-79 | @ | Ohio State | 25-7 | |
| 1/9/2010 | L 60-66 | Illinois | 18-14 | ||
| 1/14/2010 | L 45-69 | @ | Michigan | 13-17 | |
| 1/17/2010 | W 81-78 OT | at | Minnesota | 21-12 | |
| 1/21/2010 | W 67-61 | @ | Penn State | 11-19 | |
| 1/24/2010 | L 43-58 | Iowa | 8-22 | ||
| 1/30/2010 | L 70-72 | @ | Illinois | 18-14 | |
| 2/4/2010 | L 75-78 | Purdue | 24-5 | ||
| 2/7/2010 | L 61-78 | @ | Northwestern | 18-12 | |
| 2/10/2010 | L 52-69 | Ohio State | 25-7 | ||
| 2/13/2010 | L 55-83 | @ | Wisconsin | 22-8 | |
| 2/16/2010 | L 58-72 | Michigan St | 23-9 | ||
| 2/20/2010 | L 58-81 | @ | Minnesota | 21-12 | |
| 2/25/2010 | L 46-78 | Wisconsin | 22-8 | ||
| 2/28/2010 | L 57-73 | @ | Iowa | 8-22 | |
| 3/3/2010 | L 55-74 | @ | Purdue | 24-5 | |
| 3/11/2010 | L 58-73 | vs | Northwestern | 18-12 | Big Ten |
| 9-21 | 352-309 |