| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 70-55 | Pennsylvania | 6-21 | ||
| 11/16/2009 | W 80-61 | Robert Morris | 24-10 | ||
| 11/19/2009 | L 69-80 | vs | UNC Wilmington | 8-21 | C of Charleston Classic |
| 11/20/2009 | L 60-63 | vs | Tulane | 6-23 | C of Charleston Classic |
| 11/22/2009 | W 59-57 | vs | Davidson | 15-13 | C of Charleston Classic |
| 11/25/2009 | W 87-75 | Sacred Heart | 14-15 | ||
| 11/30/2009 | W 69-66 | @ | Virginia | 15-15 | Big Ten-ACC Challenge |
| 12/5/2009 | L 42-45 | @ | Temple | 27-5 | |
| 12/8/2009 | W 58-42 | UMBC | 4-25 | ||
| 12/12/2009 | L 64-66 | Virginia Tech | 22-8 | ||
| 12/19/2009 | W 104-57 | Gardner Webb | 6-20 | ||
| 12/21/2009 | W 76-57 | American | 11-20 | ||
| 12/29/2009 | L 70-75 | @ | Minnesota | 18-13 | |
| 1/3/2010 | L 46-63 | Wisconsin | 22-8 | ||
| 1/7/2010 | L 55-64 | Michigan | 13-17 | ||
| 1/12/2010 | L 53-54 | @ | Illinois | 18-14 | |
| 1/16/2010 | L 64-67 | @ | Iowa | 9-22 | |
| 1/21/2010 | L 61-67 | Indiana | 8-21 | ||
| 1/24/2010 | L 71-79 OT | @ | Wisconsin | 22-8 | |
| 1/27/2010 | L 67-77 | Illinois | 18-14 | ||
| 1/31/2010 | L 46-66 | @ | Purdue | 25-5 | |
| 2/3/2010 | L 62-75 | @ | Ohio State | 25-7 | |
| 2/6/2010 | L 64-66 | Minnesota | 18-13 | ||
| 2/13/2010 | L 54-65 | Michigan St | 22-9 | ||
| 2/17/2010 | W 81-70 | @ | Northwestern | 20-10 | |
| 2/20/2010 | W 55-51 | @ | Michigan | 13-17 | |
| 2/24/2010 | L 67-75 | Ohio State | 25-7 | ||
| 2/28/2010 | W 79-60 | Northwestern | 20-10 | ||
| 3/4/2010 | L 65-67 | @ | Michigan St | 22-9 | |
| 3/6/2010 | L 64-66 | Minnesota | 18-13 | ||
| 3/11/2010 | L 55-76 | vs | Minnesota | 18-13 | Big Ten |
| 11-20 | 338-322 |