| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 89-64 | CS Northridge | 11-20 | ||
| 11/20/2009 | W 74-63 | vs | South Dakota St | 13-15 | Paradise Jam |
| 11/22/2009 | W 85-60 | vs | Saint Joseph's | 10-19 | Paradise Jam |
| 11/23/2009 | W 73-72 | vs | Tennessee | 25-7 | Paradise Jam |
| 11/28/2009 | W 64-38 | Central Michigan | 14-15 | ||
| 12/1/2009 | W 69-58 | Wake Forest | 20-9 | Big Ten-ACC Challenge | |
| 12/5/2009 | W 101-65 | Buffalo | 18-11 | ||
| 12/9/2009 | W 86-62 | Valparaiso | 13-16 | ||
| 12/12/2009 | W 73-65 | @ | Alabama | 16-15 | |
| 12/19/2009 | W 69-49 | vs | Ball State | 14-15 | Wooden Tradition |
| 12/22/2009 | W 90-63 | SIU-Edwardsville | 3-23 | ||
| 12/29/2009 | W 67-56 | @ | Iowa | 10-20 | |
| 1/1/2010 | W 77-62 | at | West Virginia | 27-5 | |
| 1/5/2010 | W 79-60 | Minnesota | 21-11 | ||
| 1/9/2010 | L 66-73 | @ | Wisconsin | 23-7 | |
| 1/12/2010 | L 66-70 | Ohio State | 26-6 | ||
| 1/16/2010 | L 64-72 | @ | Northwestern | 19-11 | |
| 1/19/2010 | W 84-78 | @ | Illinois | 20-12 | |
| 1/23/2010 | W 69-59 | Michigan | 14-17 | ||
| 1/28/2010 | W 60-57 | Wisconsin | 23-7 | ||
| 1/31/2010 | W 66-46 | Penn State | 11-19 | ||
| 2/4/2010 | W 78-75 | @ | Indiana | 9-19 | |
| 2/9/2010 | W 76-64 | @ | Michigan St | 23-8 | |
| 2/13/2010 | W 63-40 | Iowa | 10-20 | ||
| 2/17/2010 | W 60-57 | @ | Ohio State | 26-6 | |
| 2/20/2010 | W 75-65 | Illinois | 20-12 | ||
| 2/24/2010 | W 59-58 | @ | Minnesota | 21-11 | |
| 2/28/2010 | L 44-53 | Michigan St | 23-8 | ||
| 3/3/2010 | W 74-55 | Indiana | 9-19 | ||
| 3/12/2010 | W 69-61 | vs | Northwestern | 19-11 | Big Ten |
| 3/13/2010 | L 42-69 | vs | Minnesota | 21-11 | Big Ten |
| 26-5 | 360-300 |