| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 77-55 | Northern Illinois | 10-20 | ||
| 11/18/2009 | L 54-67 | Butler | 27-4 | ||
| 11/22/2009 | W 69-62 | Tennessee St | 10-22 | Chicago Challenge | |
| 11/24/2009 | W 69-53 | Liberty | 13-15 | Chicago Challenge | |
| 11/27/2009 | W 72-58 | vs | Notre Dame | 22-10 | Chicago Challenge |
| 11/28/2009 | W 67-65 | vs | Iowa State | 15-16 | Chicago Challenge |
| 12/1/2009 | W 65-53 | @ | North Carolina St | 19-15 | Big Ten-ACC Challenge |
| 12/13/2009 | W 90-65 | North Carolina A&T | 9-21 | ||
| 12/16/2009 | W 84-54 | North Florida | 13-17 | ||
| 12/19/2009 | W 70-62 | Stanford | 14-17 | ||
| 12/22/2009 | W 74-54 | Central Connecticut | 13-17 | ||
| 12/30/2009 | L 83-89 OT | @ | Illinois | 19-13 | |
| 1/2/2010 | L 70-91 | Michigan St | 22-9 | ||
| 1/7/2010 | W 53-44 | UT Pan American | 5-27 | ||
| 1/10/2010 | W 68-62 | @ | Michigan | 14-16 | |
| 1/13/2010 | L 50-60 | Wisconsin | 22-8 | ||
| 1/16/2010 | W 72-64 | Purdue | 25-4 | ||
| 1/19/2010 | L 56-76 | @ | Ohio State | 26-7 | |
| 1/23/2010 | W 73-68 | Illinois | 19-13 | ||
| 1/26/2010 | L 61-65 | @ | Minnesota | 21-12 | |
| 1/30/2010 | L 70-79 | @ | Michigan St | 22-9 | |
| 2/2/2010 | W 67-52 | Michigan | 14-16 | ||
| 2/7/2010 | W 78-61 | Indiana | 9-19 | ||
| 2/10/2010 | L 65-78 | @ | Iowa | 9-21 | |
| 2/14/2010 | W 77-74 OT | Minnesota | 21-12 | ||
| 2/17/2010 | L 70-81 | Penn State | 9-20 | ||
| 2/21/2010 | L 63-70 | @ | Wisconsin | 22-8 | |
| 2/25/2010 | W 74-57 | Iowa | 9-21 | ||
| 2/28/2010 | L 60-79 | @ | Penn State | 9-20 | |
| 3/3/2010 | W 72-49 | Chicago St | 6-21 | ||
| 3/11/2010 | W 73-58 | vs | Indiana | 9-19 | Big Ten |
| 3/12/2010 | L 61-69 | vs | Purdue | 25-4 | Big Ten |
| 20-12 | 352-351 |