| Date | Res | Opp | OW-OL | ||
| 11/16/2009 | W 80-68 | @ | SMU | 13-15 | |
| 11/20/2009 | W 68-49 | Samford | 8-19 | ||
| 11/26/2009 | W 69-60 | vs | Clemson | 21-10 | 76 Classic |
| 11/27/2009 | L 66-73 | vs | West Virginia | 26-6 | 76 Classic |
| 11/29/2009 | W 66-65 | vs | Minnesota | 22-12 | 76 Classic |
| 12/2/2009 | W 84-59 | Prairie View A&M | 13-12 | ||
| 12/4/2009 | W 74-62 | Akron | 24-8 | ||
| 12/7/2009 | W 75-65 | North Texas | 23-7 | ||
| 12/12/2009 | L 81-84 | vs | New Mexico | 29-4 | |
| 12/19/2009 | W 71-50 | The Citadel | 14-14 | ||
| 12/22/2009 | L 64-73 | @ | Washington | 23-9 | |
| 1/2/2010 | W 89-63 | Northwestern St | 7-17 | ||
| 1/5/2010 | W 82-41 | North Dakota | 6-20 | ||
| 1/9/2010 | W 64-53 | Nebraska | 15-16 | ||
| 1/12/2010 | L 65-88 | @ | Kansas St | 24-7 | |
| 1/16/2010 | L 67-72 OT | @ | Texas | 23-8 | |
| 1/19/2010 | W 65-62 | Oklahoma | 14-16 | ||
| 1/23/2010 | W 67-63 | Colorado | 12-16 | ||
| 1/27/2010 | L 69-76 | @ | Oklahoma St | 20-10 | |
| 1/30/2010 | W 85-70 | Texas Tech | 18-12 | ||
| 2/3/2010 | W 77-74 | @ | Missouri | 23-8 | |
| 2/6/2010 | W 78-71 | Baylor | 22-6 | ||
| 2/13/2010 | W 67-65 | @ | Texas Tech | 18-12 | |
| 2/15/2010 | L 54-59 | Kansas | 30-2 | ||
| 2/20/2010 | W 60-56 | @ | Iowa State | 15-16 | |
| 2/24/2010 | L 66-70 | @ | Baylor | 22-6 | |
| 2/27/2010 | W 74-58 | Texas | 23-8 | ||
| 3/3/2010 | W 76-61 | Oklahoma St | 20-10 | ||
| 3/6/2010 | W 78-71 | Baylor | 22-6 | ||
| 3/11/2010 | W 70-64 | vs | Nebraska | 15-16 | Big 12 |
| 3/12/2010 | L 66-79 | vs | Kansas | 30-2 | Big 12 |
| 22-9 | 445-270 |