| Date | Res | Opp | OW-OL | ||
| 11/15/2009 | W 75-46 | IPFW | 14-15 | ||
| 11/18/2009 | W 58-42 | Oakland | 24-7 | ||
| 11/23/2009 | W 65-61 | vs | Arizona | 15-15 | Maui Invitational |
| 11/24/2009 | L 61-74 | vs | Gonzaga | 25-6 | Maui Invitational |
| 11/25/2009 | W 78-69 | vs | Maryland | 21-7 | Maui Invitational |
| 12/2/2009 | W 73-69 | Duke | 29-4 | Big Ten-ACC Challenge | |
| 12/5/2009 | W 79-46 | Grambling St | 7-19 | ||
| 12/9/2009 | L 84-88 OT | @ | UW Green Bay | 19-11 | |
| 12/12/2009 | W 72-63 | Marquette | 23-9 | ||
| 12/16/2009 | W 90-42 | Cal Poly | 12-18 | ||
| 12/23/2009 | W 68-58 | UW Milwaukee | 17-13 | ||
| 12/27/2009 | W 79-43 | UIC | 8-21 | ||
| 12/31/2009 | W 65-43 | Ohio State | 26-6 | ||
| 1/3/2010 | W 63-46 | @ | Penn State | 11-18 | |
| 1/6/2010 | L 47-54 | @ | Michigan St | 23-8 | |
| 1/9/2010 | W 73-66 | Purdue | 25-4 | ||
| 1/13/2010 | W 60-50 | @ | Northwestern | 20-10 | |
| 1/16/2010 | L 51-60 | @ | Ohio State | 26-6 | |
| 1/20/2010 | W 54-48 | Michigan | 14-15 | ||
| 1/24/2010 | W 79-71 OT | Penn State | 11-18 | ||
| 1/28/2010 | L 57-60 | @ | Purdue | 25-4 | |
| 2/2/2010 | W 67-49 | Michigan St | 23-8 | ||
| 2/6/2010 | W 62-44 | @ | Michigan | 14-15 | |
| 2/9/2010 | L 56-63 | Illinois | 18-13 | ||
| 2/13/2010 | W 83-55 | Indiana | 9-19 | ||
| 2/18/2010 | L 52-68 | @ | Minnesota | 21-13 | |
| 2/21/2010 | W 70-63 | Northwestern | 20-10 | ||
| 2/25/2010 | W 78-46 | @ | Indiana | 9-19 | |
| 3/3/2010 | W 67-40 | Iowa | 10-21 | ||
| 3/6/2010 | W 62-44 | @ | Michigan | 14-15 | |
| 3/7/2010 | W 72-57 | @ | Illinois | 18-13 | |
| 3/12/2010 | L 54-58 | vs | Illinois | 18-13 | Big Ten |
| 24-8 | 391-272 |