| Date | Res | Opp | OW-OL | ||
| 11/17/2009 | W 83-68 | UT Martin | 2-25 | ||
| 11/22/2009 | W 100-44 | UT Pan American | 5-27 | South Padre Island | |
| 11/24/2009 | W 99-56 | Chattanooga | 12-17 | South Padre Island | |
| 11/27/2009 | W 66-61 | vs | Old Dominion | 25-8 | South Padre Island |
| 11/28/2009 | L 52-59 | vs | Richmond | 25-8 | South Padre Island |
| 12/2/2009 | L 83-89 | @ | Vanderbilt | 22-8 | |
| 12/5/2009 | W 106-69 | Oregon | 15-16 | ||
| 12/9/2009 | L 59-60 | @ | Oral Roberts | 18-14 | |
| 12/12/2009 | W 87-36 | Fairleigh Dickinson | 12-20 | ||
| 12/19/2009 | W 88-70 | UA Pine Bluff | 18-14 | ||
| 12/23/2009 | W 81-68 | vs | Illinois | 20-13 | |
| 12/27/2009 | W 94-79 | Austin Peay | 15-15 | ||
| 12/30/2009 | W 91-57 | UMKC | 10-17 | ||
| 1/2/2010 | W 89-61 | Georgia | 15-15 | ||
| 1/6/2010 | W 74-45 | Savannah St | 7-15 | ||
| 1/9/2010 | W 74-68 | Kansas St | 24-6 | ||
| 1/13/2010 | W 94-89 OT | @ | Texas Tech | 18-13 | |
| 1/16/2010 | L 61-66 | @ | Oklahoma | 13-17 | |
| 1/23/2010 | W 70-53 | Nebraska | 14-16 | ||
| 1/25/2010 | L 65-84 | @ | Kansas | 31-2 | |
| 1/30/2010 | W 95-80 | Oklahoma St | 21-10 | ||
| 2/3/2010 | L 74-77 | Texas A&M | 21-9 | ||
| 2/6/2010 | W 84-66 | @ | Colorado | 12-14 | |
| 2/10/2010 | W 65-56 | Iowa State | 15-15 | ||
| 2/13/2010 | L 62-64 | @ | Baylor | 22-8 | |
| 2/17/2010 | W 82-77 | Texas | 24-8 | ||
| 2/20/2010 | W 74-59 | @ | Nebraska | 14-16 | |
| 2/24/2010 | W 92-63 | Colorado | 12-14 | ||
| 2/27/2010 | L 53-63 | @ | Kansas St | 24-6 | |
| 3/2/2010 | W 69-67 OT | @ | Iowa State | 15-15 | |
| 3/6/2010 | W 84-66 | @ | Colorado | 12-14 | |
| 3/10/2010 | L 60-75 | vs | Nebraska | 14-16 | Big 12 |
| 23-9 | 436-350 |