| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | L 54-83 | @ | Tennessee | 24-8 | |
| 11/15/2009 | W 80-77 | @ | Akron | 24-8 | Glenn Wilkes Classic |
| 11/20/2009 | L 63-77 | vs | IUPUI | 21-10 | Glenn Wilkes Classic |
| 11/21/2009 | L 59-66 | vs | North Carolina St | 18-16 | Glenn Wilkes Classic |
| 11/22/2009 | W 69-67 | vs | Niagara | 18-14 | Glenn Wilkes Classic |
| 11/28/2009 | L 72-78 | Drake | 13-19 | ||
| 12/3/2009 | W 76-71 OT | SE Missouri St | 6-22 | ||
| 12/5/2009 | W 73-60 | Eastern Illinois | 17-10 | ||
| 12/9/2009 | W 68-66 | @ | Ohio | 20-14 | |
| 12/19/2009 | L 69-90 | @ | Kentucky | 32-2 | |
| 12/22/2009 | W 71-68 | Evansville | 8-21 | ||
| 12/27/2009 | L 79-94 | @ | Missouri | 22-9 | |
| 1/2/2010 | L 65-68 OT | @ | Morehead St | 20-8 | |
| 1/4/2010 | L 71-76 | @ | Eastern Kentucky | 18-11 | |
| 1/7/2010 | W 90-72 | UT Martin | 2-24 | ||
| 1/9/2010 | L 53-69 | Murray St | 24-4 | ||
| 1/16/2010 | W 79-77 | Tennessee St | 9-22 | ||
| 1/21/2010 | L 90-94 | @ | Tennessee Tech | 11-16 | |
| 1/23/2010 | W 66-64 OT | @ | Jacksonville St | 9-18 | |
| 1/28/2010 | W 80-76 | Eastern Kentucky | 18-11 | ||
| 1/31/2010 | W 56-55 | Morehead St | 20-8 | ||
| 2/4/2010 | W 74-69 | @ | UT Martin | 2-24 | |
| 2/6/2010 | L 63-65 | @ | Murray St | 24-4 | |
| 2/13/2010 | L 67-76 | @ | Tennessee St | 9-22 | |
| 2/15/2010 | W 83-63 | Jacksonville St | 9-18 | ||
| 2/18/2010 | W 77-72 OT | Tennessee Tech | 11-16 | ||
| 2/20/2010 | L 80-89 | Oral Roberts | 18-14 | Bracket Buster | |
| 2/25/2010 | L 73-83 | @ | Eastern Illinois | 17-10 | |
| 2/27/2010 | W 71-68 OT | @ | SE Missouri St | 6-22 | |
| 3/2/2010 | L 65-68 | Tennessee Tech | 11-16 | Ohio Valley | |
| 3/6/2010 | L 63-65 | @ | Murray St | 24-4 | |
| 15-16 | 334-270 |