| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 92-54 | Loyola (Chicago) | 12-16 | ||
| 11/15/2009 | W 82-50 | Western Illinois | 10-16 | ||
| 11/19/2009 | W 80-70 | vs | Boston U | 19-12 | Puerto Rico Shootout |
| 11/20/2009 | L 74-86 | vs | Mississippi | 20-10 | Puerto Rico Shootout |
| 11/22/2009 | W 83-75 | vs | Dayton | 21-10 | Puerto Rico Shootout |
| 11/28/2009 | W 70-57 | IUPUI | 22-9 | ||
| 12/5/2009 | W 86-69 | Washington St | 16-13 | ||
| 12/8/2009 | W 71-56 | Xavier | 23-8 | ||
| 12/12/2009 | W 95-80 | @ | UNLV | 24-7 | |
| 12/19/2009 | W 87-74 | vs | Alabama | 16-15 | |
| 12/21/2009 | W 90-76 | UA Pine Bluff | 18-14 | ||
| 12/29/2009 | W 85-56 | Cleveland St | 15-15 | ||
| 1/3/2010 | W 91-69 | South Dakota | 18-8 | ||
| 1/9/2010 | L 68-74 | @ | Missouri | 22-8 | |
| 1/12/2010 | W 88-65 | Texas A&M | 22-8 | ||
| 1/16/2010 | W 87-81 | @ | Colorado | 12-15 | |
| 1/18/2010 | W 71-62 | Texas | 24-8 | ||
| 1/23/2010 | L 69-73 | Oklahoma St | 20-10 | ||
| 1/26/2010 | W 76-74 | @ | Baylor | 23-6 | |
| 1/30/2010 | L 79-81 OT | Kansas | 29-2 | ||
| 2/2/2010 | W 76-57 | @ | Nebraska | 15-16 | |
| 2/6/2010 | W 79-75 | @ | Iowa State | 14-16 | |
| 2/13/2010 | W 68-51 | Colorado | 12-15 | ||
| 2/17/2010 | W 91-87 | Nebraska | 15-16 | ||
| 2/20/2010 | W 83-68 | @ | Oklahoma | 14-16 | |
| 2/23/2010 | W 83-64 | @ | Texas Tech | 18-13 | |
| 2/27/2010 | W 63-53 | Missouri | 22-8 | ||
| 3/3/2010 | L 65-82 | @ | Kansas | 29-2 | |
| 3/6/2010 | L 82-85 | @ | Iowa State | 14-16 | |
| 3/11/2010 | W 83-64 | vs | Oklahoma St | 20-10 | Big 12 |
| 3/12/2010 | W 82-75 | vs | Baylor | 23-6 | Big 12 |
| 3/13/2010 | L 64-72 | vs | Kansas | 29-2 | Big 12 |
| 25-7 | 447-271 |