| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 88-49 | South Dakota | 18-8 | Duel in the Desert | |
| 11/14/2009 | W 66-59 | Texas A&M CC | 14-14 | Duel in the Desert | |
| 11/15/2009 | W 64-60 | Oregon St | 15-15 | Duel in the Desert | |
| 11/19/2009 | W 94-75 | Northwestern St | 7-17 | ||
| 11/21/2009 | W 77-54 | Lamar | 11-16 | ||
| 11/24/2009 | W 63-61 | @ | Stephen F. Austin | 20-8 | |
| 11/28/2009 | W 74-53 | Samford | 8-19 | ||
| 12/3/2009 | W 99-92 OT | Washington | 24-8 | ||
| 12/8/2009 | W 80-70 | @ | TCU | 12-17 | |
| 12/19/2009 | L 83-85 | @ | Wichita St | 22-9 | |
| 12/22/2009 | W 100-87 | Stanford | 14-17 | ||
| 12/29/2009 | L 75-90 | @ | New Mexico | 29-4 | |
| 1/1/2010 | W 76-75 | at | McNeese St | 7-19 | |
| 1/3/2010 | W 86-78 | UTEP | 26-5 | ||
| 1/9/2010 | L 52-81 | @ | Oklahoma St | 20-9 | |
| 1/13/2010 | L 89-94 OT | Missouri | 22-9 | ||
| 1/16/2010 | L 63-89 | @ | Kansas | 30-2 | |
| 1/20/2010 | W 78-71 | Iowa State | 15-16 | ||
| 1/23/2010 | W 75-65 | Oklahoma | 14-15 | ||
| 1/27/2010 | L 83-95 | @ | Texas | 22-9 | |
| 1/30/2010 | L 70-85 | @ | Texas A&M | 20-9 | |
| 2/6/2010 | W 81-74 | Oklahoma St | 20-9 | ||
| 2/9/2010 | W 72-71 | @ | Oklahoma | 14-15 | |
| 2/13/2010 | L 65-67 | Texas A&M | 20-9 | ||
| 2/16/2010 | L 70-88 | @ | Baylor | 21-8 | |
| 2/20/2010 | L 67-71 | Texas | 22-9 | ||
| 2/23/2010 | L 64-83 | Kansas St | 24-7 | ||
| 2/27/2010 | L 79-83 2 OT | @ | Nebraska | 14-18 | |
| 3/2/2010 | L 68-86 | Baylor | 21-8 | ||
| 3/6/2010 | W 81-74 | Oklahoma St | 20-9 | ||
| 3/10/2010 | W 82-67 | vs | Colorado | 12-16 | Big 12 |
| 3/11/2010 | L 68-80 | vs | Kansas | 30-2 | Big 12 |
| 18-14 | 441-294 |