| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 86-58 | Norfolk St | 12-18 | ||
| 11/15/2009 | W 71-69 | Hartford | 9-20 | ||
| 11/16/2009 | W 61-45 | Southern U | 5-23 | ||
| 11/26/2009 | L 76-79 | vs | Alabama | 15-16 | Old Spice Classic |
| 11/27/2009 | W 72-62 OT | vs | Iona | 21-9 | Old Spice Classic |
| 11/29/2009 | W 69-64 | vs | Xavier | 23-8 | Old Spice Classic |
| 12/3/2009 | W 64-61 | @ | Arizona St | 21-10 | |
| 12/15/2009 | W 90-60 | Jackson St | 18-11 | ||
| 12/20/2009 | W 94-63 | UT Arlington | 13-12 | ||
| 12/30/2009 | W 70-47 | vs | Arkansas | 15-16 | |
| 1/2/2010 | W 85-74 | @ | South Carolina | 14-16 | |
| 1/6/2010 | W 79-63 | Morgan St | 27-8 | ||
| 1/9/2010 | W 91-60 | Oklahoma | 14-15 | ||
| 1/12/2010 | L 71-78 | @ | Colorado | 11-17 | |
| 1/16/2010 | W 83-70 | Oklahoma St | 20-10 | ||
| 1/20/2010 | L 75-81 | @ | Kansas | 31-2 | |
| 1/23/2010 | W 71-45 | Massachusetts | 10-20 | ||
| 1/26/2010 | L 74-76 | Kansas St | 23-7 | ||
| 1/30/2010 | W 80-77 OT | @ | Texas | 24-7 | |
| 2/3/2010 | W 84-63 | Iowa State | 15-16 | ||
| 2/6/2010 | L 71-78 | @ | Texas A&M | 20-8 | |
| 2/10/2010 | W 55-53 | @ | Nebraska | 15-17 | |
| 2/13/2010 | W 64-62 | Missouri | 23-8 | ||
| 2/16/2010 | W 88-70 | Texas Tech | 18-12 | ||
| 2/20/2010 | L 75-82 | @ | Oklahoma St | 20-10 | |
| 2/24/2010 | W 70-66 | Texas A&M | 20-8 | ||
| 2/27/2010 | W 70-63 | @ | Oklahoma | 14-15 | |
| 3/2/2010 | W 86-68 | @ | Texas Tech | 18-12 | |
| 3/6/2010 | L 71-78 | @ | Texas A&M | 20-8 | |
| 3/11/2010 | W 86-67 | vs | Texas | 24-7 | Big 12 |
| 3/12/2010 | L 75-82 | vs | Kansas St | 23-7 | Big 12 |
| 23-8 | 417-306 |