| Date | Res | Opp | OW-OL | ||
| 11/14/2009 | W 86-64 | Seattle | 16-13 | ||
| 11/18/2009 | W 93-61 | Southern U | 5-23 | ||
| 11/21/2009 | W 82-68 | North Texas | 23-7 | ||
| 11/24/2009 | W 80-58 | Prairie View A&M | 13-12 | ||
| 11/27/2009 | W 68-57 | vs | Bradley | 16-13 | Las Vegas Invitational |
| 11/28/2009 | W 77-55 | vs | Utah | 14-15 | Las Vegas Invitational |
| 12/2/2009 | L 65-86 | @ | Tulsa | 21-11 | |
| 12/5/2009 | W 61-55 | UT San Antonio | 16-10 | ||
| 12/13/2009 | W 81-66 | UA Pine Bluff | 18-14 | ||
| 12/16/2009 | W 71-70 | @ | Stanford | 14-17 | |
| 12/21/2009 | W 77-62 | vs | La Salle | 12-17 | |
| 12/29/2009 | W 66-50 | Pacific | 20-10 | ||
| 1/2/2010 | L 59-63 | vs | Rhode Island | 23-8 | |
| 1/5/2010 | W 79-61 | Coppin St | 5-22 | ||
| 1/9/2010 | W 81-52 | Texas Tech | 16-13 | ||
| 1/11/2010 | L 57-62 OT | @ | Oklahoma | 13-15 | |
| 1/16/2010 | L 70-83 | @ | Baylor | 22-7 | |
| 1/20/2010 | W 90-78 | Colorado | 12-16 | ||
| 1/23/2010 | W 73-69 | @ | Kansas St | 24-6 | |
| 1/27/2010 | W 76-69 | Texas A&M | 21-8 | ||
| 1/30/2010 | L 80-95 | @ | Missouri | 22-9 | |
| 2/1/2010 | L 60-72 | Texas | 22-9 | ||
| 2/6/2010 | L 74-81 | @ | Texas Tech | 16-13 | |
| 2/13/2010 | W 97-76 | Oklahoma | 13-15 | ||
| 2/17/2010 | W 69-64 | @ | Iowa State | 15-16 | |
| 2/20/2010 | W 82-75 | Baylor | 22-7 | ||
| 2/24/2010 | L 59-69 | @ | Texas | 22-9 | |
| 2/27/2010 | W 85-77 | Kansas | 32-1 | ||
| 3/3/2010 | L 61-76 | @ | Texas A&M | 21-8 | |
| 3/6/2010 | L 74-81 | @ | Texas Tech | 16-13 | |
| 3/10/2010 | W 81-67 | vs | Oklahoma | 13-15 | Big 12 |
| 3/11/2010 | L 64-83 | vs | Kansas St | 24-6 | Big 12 |
| 21-11 | 415-292 |