| Date | Res | Opp | OW-OL | ||
| 11/12/2009 | L 44-72 | at | Ohio State | 26-7 | Coaches vs Cancer |
| 11/20/2009 | L 43-71 | vs | Murray St | 26-4 | Coaches vs Cancer |
| 11/22/2009 | W 81-68 | @ | Florida Intl | 6-24 | Coaches vs Cancer |
| 11/23/2009 | W 79-66 | vs | NCCU | 4-21 | Coaches vs Cancer |
| 11/28/2009 | W 53-51 | UMBC | 4-25 | ||
| 12/2/2009 | W 72-64 | Norfolk St | 12-18 | ||
| 12/5/2009 | L 44-49 | Georgia St | 9-20 | ||
| 12/12/2009 | L 64-75 | @ | Eastern Michigan | 15-15 | |
| 12/17/2009 | W 78-57 | @ | Gardner Webb | 6-20 | |
| 12/23/2009 | W 85-73 | Fordham | 2-25 | ||
| 12/29/2009 | L 76-80 | @ | Stanford | 13-18 | |
| 1/2/2010 | L 61-73 | @ | Northeastern | 19-12 | |
| 1/4/2010 | W 71-65 | Delaware | 7-22 | ||
| 1/6/2010 | L 72-74 | @ | Old Dominion | 23-9 | |
| 1/9/2010 | W 69-66 | Towson | 8-19 | ||
| 1/14/2010 | L 78-85 | @ | William & Mary | 20-9 | |
| 1/16/2010 | L 71-82 | George Mason | 15-14 | ||
| 1/20/2010 | L 57-78 | @ | Drexel | 15-15 | |
| 1/23/2010 | L 64-67 | @ | UNC Wilmington | 8-21 | |
| 1/25/2010 | W 67-63 | Radford | 17-11 | ||
| 1/27/2010 | W 65-63 | William & Mary | 20-9 | ||
| 1/30/2010 | L 68-70 | @ | George Mason | 15-14 | |
| 2/3/2010 | L 48-68 | Hofstra | 16-14 | ||
| 2/8/2010 | L 78-81 | @ | Towson | 8-19 | |
| 2/10/2010 | L 44-64 | Old Dominion | 23-9 | ||
| 2/13/2010 | W 76-71 | VCU | 20-8 | ||
| 2/16/2010 | L 72-77 | @ | Georgia St | 9-20 | |
| 2/20/2010 | L 66-70 | @ | Canisius | 13-17 | Bracket Buster |
| 2/22/2010 | W 96-86 | Longwood | 9-18 | ||
| 2/24/2010 | L 62-76 | @ | VCU | 20-8 | |
| 2/27/2010 | L 64-67 | Drexel | 15-15 | ||
| 12-19 | 313-386 |