| Date | Res | Opp | OW-OL | ||
| 11/15/2009 | L 58-89 | Wake Forest | 19-10 | ||
| 11/17/2009 | L 68-74 | @ | Campbell | 17-11 | |
| 11/20/2009 | L 66-105 | vs | Tennessee | 24-8 | Paradise Jam |
| 11/21/2009 | L 68-74 | vs | Northern Iowa | 26-4 | Paradise Jam |
| 11/23/2009 | W 82-73 | vs | South Dakota St | 13-15 | Paradise Jam |
| 11/28/2009 | W 82-61 | @ | UNC Greensboro | 7-22 | |
| 12/2/2009 | L 68-80 | @ | Charlotte | 19-12 | |
| 12/16/2009 | L 63-80 | Clemson | 20-11 | ||
| 12/22/2009 | L 80-84 OT | George Washington | 15-14 | ||
| 12/29/2009 | L 74-82 | @ | VCU | 20-9 | |
| 1/3/2010 | W 68-58 | NCCU | 4-21 | ||
| 1/6/2010 | L 68-76 | @ | UAB | 23-7 | |
| 1/9/2010 | L 65-83 | Marshall | 17-9 | ||
| 1/13/2010 | L 57-77 | @ | Memphis | 21-10 | |
| 1/16/2010 | L 55-74 | Houston | 16-15 | ||
| 1/23/2010 | L 53-68 | @ | Southern Miss | 15-13 | |
| 1/24/2010 | W 61-46 | @ | Tulane | 7-21 | |
| 1/30/2010 | L 58-69 | Rice | 6-22 | ||
| 2/2/2010 | L 56-67 | UCF | 12-16 | ||
| 2/6/2010 | L 49-100 | @ | Marshall | 17-9 | |
| 2/10/2010 | W 71-68 | Tulane | 7-21 | ||
| 2/13/2010 | L 76-100 | @ | UTEP | 25-6 | |
| 2/20/2010 | W 76-65 | @ | Rice | 6-22 | |
| 2/24/2010 | L 54-59 | SMU | 12-16 | ||
| 2/27/2010 | L 73-85 | Tulsa | 21-11 | ||
| 3/2/2010 | W 68-66 | @ | UCF | 12-16 | |
| 3/6/2010 | L 49-100 | @ | Marshall | 17-9 | |
| 3/10/2010 | L 80-93 | vs | Houston | 16-15 | Conference USA |
| 7-21 | 359-283 |