| Date | Res | Opp | OW-OL | ||
| 11/9/2009 | L 70-75 | at | California | 22-10 | Coaches vs Cancer |
| 11/20/2009 | W 71-43 | vs | James Madison | 12-18 | Coaches vs Cancer |
| 11/22/2009 | W 84-61 | vs | NCCU | 4-21 | Coaches vs Cancer |
| 11/23/2009 | W 84-71 | @ | Florida Intl | 6-24 | Coaches vs Cancer |
| 12/3/2009 | W 62-60 | Eastern Kentucky | 19-10 | ||
| 12/5/2009 | W 86-56 | Morehead St | 20-8 | ||
| 12/12/2009 | W 61-57 | @ | East Tenn St | 18-13 | |
| 12/15/2009 | L 81-87 | @ | Louisiana Tech | 22-9 | |
| 12/19/2009 | W 73-62 | Chattanooga | 12-17 | ||
| 12/22/2009 | L 72-83 | @ | Western Kentucky | 20-13 | |
| 12/30/2009 | W 82-51 | @ | SIU-Edwardsville | 3-22 | |
| 1/4/2010 | W 83-59 | UT Martin | 2-24 | ||
| 1/7/2010 | W 80-59 | @ | Tennessee St | 10-20 | |
| 1/9/2010 | W 69-53 | @ | Austin Peay | 15-13 | |
| 1/11/2010 | W 75-59 | Eastern Illinois | 18-9 | ||
| 1/14/2010 | W 92-68 | Jacksonville St | 9-18 | ||
| 1/16/2010 | W 88-66 | Tennessee Tech | 13-15 | ||
| 1/21/2010 | W 60-51 | @ | Eastern Illinois | 18-9 | |
| 1/23/2010 | W 80-61 | @ | SE Missouri St | 6-22 | |
| 1/27/2010 | W 86-49 | SIU-Edwardsville | 3-22 | ||
| 1/30/2010 | W 77-45 | @ | UT Martin | 2-24 | |
| 2/4/2010 | W 76-54 | Tennessee St | 10-20 | ||
| 2/6/2010 | W 65-63 | Austin Peay | 15-13 | ||
| 2/11/2010 | W 94-62 | @ | Tennessee Tech | 13-15 | |
| 2/13/2010 | W 75-67 | @ | Jacksonville St | 9-18 | |
| 2/16/2010 | W 80-68 | SE Missouri St | 6-22 | ||
| 2/20/2010 | W 75-66 | Morgan St | 27-8 | Bracket Buster | |
| 2/25/2010 | L 65-70 | @ | Morehead St | 20-8 | |
| 2/27/2010 | W 88-74 | @ | Eastern Kentucky | 19-10 | |
| 3/2/2010 | W 84-51 | Tennessee St | 10-20 | Ohio Valley | |
| 3/6/2010 | W 65-63 | Austin Peay | 15-13 | ||
| 27-4 | 258-294 |