| Date | Res | Opp | OW-OL | ||
| 11/14/2009 | W 81-77 | @ | Oakland | 24-7 | |
| 11/20/2009 | L 56-63 | vs | The Citadel | 13-15 | Hispanic Fund Classic |
| 11/21/2009 | W 76-51 | vs | UM Eastern Shore | 11-21 | Hispanic Fund Classic |
| 11/22/2009 | L 61-75 | @ | Missouri St | 20-11 | Hispanic Fund Classic |
| 11/24/2009 | W 86-76 | @ | SE Missouri St | 6-23 | |
| 11/30/2009 | W 75-58 | Canisius | 14-16 | ||
| 12/5/2009 | L 60-111 | @ | Ohio State | 26-7 | |
| 12/12/2009 | W 75-64 | James Madison | 12-18 | ||
| 12/19/2009 | L 65-66 | @ | Georgia St | 10-20 | |
| 12/22/2009 | L 56-58 | Samford | 7-20 | ||
| 1/3/2010 | W 59-47 | Chicago St | 6-21 | ||
| 1/9/2010 | L 47-61 | @ | Western Michigan | 17-14 | |
| 1/13/2010 | W 74-59 | Toledo | 3-27 | ||
| 1/16/2010 | L 69-77 | @ | Northern Illinois | 9-19 | |
| 1/20/2010 | L 63-71 | @ | Central Michigan | 12-16 | |
| 1/23/2010 | W 57-53 | Ball State | 14-14 | ||
| 1/27/2010 | L 61-64 | Bowling Green | 12-17 | ||
| 1/30/2010 | L 51-61 | @ | Miami-Ohio | 14-18 | |
| 2/1/2010 | W 62-59 | @ | Akron | 23-8 | |
| 2/4/2010 | L 68-75 | Kent St | 21-9 | ||
| 2/6/2010 | W 70-61 | Ohio | 20-13 | ||
| 2/10/2010 | L 67-84 | @ | Buffalo | 17-12 | |
| 2/14/2010 | W 66-52 | Western Michigan | 17-14 | ||
| 2/17/2010 | W 58-42 | @ | Toledo | 3-27 | |
| 2/20/2010 | L 66-68 | @ | Detroit | 17-14 | Bracket Buster |
| 2/24/2010 | W 72-67 | @ | Ball State | 14-14 | |
| 2/27/2010 | W 66-60 | Northern Illinois | 9-19 | ||
| 3/4/2010 | L 55-56 | Central Michigan | 12-16 | ||
| 3/6/2010 | W 70-61 | Ohio | 20-13 | ||
| 3/7/2010 | W 65-59 | Northern Illinois | 9-19 | Mid-American | |
| 3/11/2010 | L 89-97 2 OT | vs | Akron | 23-8 | Mid-American |
| 16-15 | 328-360 |