| Date | Res | Opp | OW-OL | ||
| 11/15/2008 | W 92-47 | Elon | 9-19 | ||
| 11/20/2008 | W 86-54 | Longwood | 13-13 | ||
| 11/25/2008 | W 76-42 | vs | Delaware St | 7-22 | |
| 11/28/2008 | W 87-68 | vs | Iowa | 15-16 | |
| 11/29/2008 | L 43-54 | vs | Kentucky | 21-14 | |
| 12/3/2008 | W 80-78 | @ | Mississippi | 16-14 | |
| 12/6/2008 | W 53-43 | Cleveland St | 23-10 | ||
| 12/9/2008 | L 65-68 | vs | Davidson | 25-8 | |
| 12/13/2008 | W 68-63 | @ | Duquesne | 21-12 | |
| 12/20/2008 | W 82-46 | Miami-Ohio | 17-12 | ||
| 12/23/2008 | W 89-54 | Radford | 18-11 | ||
| 12/27/2008 | W 76-48 | @ | Ohio State | 22-10 | |
| 1/3/2009 | W 92-66 | @ | Seton Hall | 16-14 | |
| 1/6/2009 | L 55-61 | Connecticut | 29-4 | ||
| 1/10/2009 | L 53-75 | @ | Marquette | 24-10 | |
| 1/14/2009 | W 87-76 | vs | Marshall | 12-16 | |
| 1/17/2009 | W 62-59 | South Florida | 9-20 | ||
| 1/22/2009 | W 75-58 | @ | Georgetown | 16-14 | |
| 1/25/2009 | L 67-79 | Pittsburgh | 28-3 | ||
| 1/28/2009 | W 75-52 | St. John's | 16-17 | ||
| 1/31/2009 | L 63-69 | @ | Louisville | 28-5 | |
| 2/4/2009 | L 61-74 | @ | Syracuse | 25-9 | |
| 2/7/2009 | W 86-59 | Providence | 19-13 | ||
| 2/9/2009 | L 59-70 | @ | Pittsburgh | 28-3 | |
| 2/13/2009 | W 93-72 | Villanova | 29-6 | ||
| 2/18/2009 | W 79-68 | Notre Dame | 20-12 | ||
| 2/22/2009 | W 74-56 | @ | Rutgers | 11-20 | |
| 2/26/2009 | L 61-65 | @ | Cincinnati | 16-14 | |
| 3/1/2009 | W 64-50 | @ | South Florida | 9-20 | |
| 3/4/2009 | W 82-63 | DePaul | 9-23 | ||
| 3/7/2009 | L 59-62 | Louisville | 28-5 | ||
| 3/11/2009 | W 74-62 | vs | Notre Dame | 20-12 | Big East |
| 3/12/2009 | W 74-60 | vs | Pittsburgh | 28-3 | Big East |
| 3/13/2009 | L 69-74 OT | vs | Syracuse | 25-9 | Big East |
| 3/20/2009 | L 60-68 | vs | Dayton | 26-8 | Midwest |
| 23-12 | 540-369 |