| 9 Nov | Bellarmine 67 | at | Louisville 66 | vs ASUN | ||
| 12 Nov | Wright St 73 | at | Louisville 72 | vs HL | ||
| 15 Nov | Appalachian St 61 | at | Louisville 60 | vs SBC | ||
| 21 Nov | Arkansas 80 | vs | Louisville 54 | Lahaina, HI | vs SEC | |
| 22 Nov | Texas Tech 70 | vs | Louisville 38 | Lahaina, HI | vs B12 | |
| 23 Nov | Cincinnati 81 | vs | Louisville 62 | Lahaina, HI | vs AAC | |
| 29 Nov | Maryland 79 | at | Louisville 54 | vs B10 | ||
| 4 Dec | Miami FL 80 | at | Louisville 53 | |||
| 10 Dec | Louisville 53 | at | Florida St 75 | |||
| 14 Dec | WKU 83 | at | Louisville 94 | vs CUSA | ||
| 17 Dec | Florida A&M 55 | at | Louisville 61 | vs SWAC | ||
| 20 Dec | Lipscomb 75 | at | Louisville 67 | vs ASUN | ||
| 22 Dec | Louisville 64 | at | NC State 76 | |||
| 31 Dec | Louisville 63 | at | Kentucky 86 | at SEC | ||
| 3 Jan | Syracuse 70 | at | Louisville 69 | |||
| 7 Jan | Wake Forest 80 | at | Louisville 72 | |||
| 11 Jan | Louisville 70 | at | Clemson 83 | |||
| 14 Jan | North Carolina 80 | at | Louisville 59 | |||
| 18 Jan | Pittsburgh 75 | at | Louisville 54 | |||
| 25 Jan | Louisville 65 | at | Boston College 75 | |||
| 28 Jan | Louisville 62 | at | Notre Dame 76 | |||
| 1 Feb | Georgia Tech 58 | at | Louisville 68 | |||
| 4 Feb | Florida St 81 | at | Louisville 78 | |||
| 7 Feb | Louisville 57 | at | Pittsburgh 91 | |||
| 11 Feb | Louisville 85 | at | Miami FL 93 | |||
| 15 Feb | Virginia 61 | at | Louisville 58 | |||
| 18 Feb | Clemson 73 | at | Louisville 83 | |||
| 20 Feb | Louisville 62 | at | Duke 79 | |||
| 25 Feb | Louisville 67 | at | Georgia Tech 83 | |||
| 28 Feb | Virginia Tech 71 | at | Louisville 54 | |||
| 4 Mar | Louisville 60 | at | Virginia 75 | |||
| 7 Mar | Boston College 80 | vs | Louisville 62 | Greensboro, NC |
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