| 7 Nov | Nicholls St 75 | at | Arizona 117 | at P12 | ||
| 10 Nov | Nicholls St 68 | at | Wyoming 79 | at MWC | ||
| 19 Nov | Nicholls St 73 | at | BYU 87 | at WCC | ||
| 22 Nov | Jarvis Chr 52 | at | Nicholls St 97 | vs ND1 | ||
| 25 Nov | UC Irvine 83 | vs | Nicholls St 56 | Paradise, NV | vs BWC | |
| 26 Nov | Nicholls St 72 | vs | San Diego 70 | Paradise, NV | vs WCC | |
| 29 Nov | Champion Bap 50 | at | Nicholls St 115 | vs ND1 | ||
| 7 Dec | Nicholls St 71 | at | Texas Tech 78 | at B12 | ||
| 11 Dec | Rust 65 | at | Nicholls St 85 | vs ND1 | ||
| 15 Dec | SE Louisiana 73 | at | Nicholls St 88 | |||
| 17 Dec | Nicholls St 66 | at | Mississippi St 68 | at SEC | ||
| 19 Dec | Trinity Bap 46 | at | Nicholls St 90 | vs ND1 | ||
| 28 Dec | Nicholls St 56 | at | Baylor 85 | at B12 | ||
| 5 Jan | Nicholls St 66 | at | TX A&M Commerce 63 | |||
| 7 Jan | Nicholls St 48 | at | Northwestern LA 68 | |||
| 12 Jan | Nicholls St 66 | at | Lamar 69 | at WAC | ||
| 14 Jan | Northwestern LA 63 | at | Nicholls St 77 | |||
| 19 Jan | McNeese St 64 | at | Nicholls St 73 | |||
| 21 Jan | Nicholls St 71 | at | McNeese St 68 | |||
| 26 Jan | Nicholls St 86 | at | TAM C. Christi 96 | |||
| 28 Jan | Nicholls St 67 | at | Incarnate Word 69 | |||
| 4 Feb | Nicholls St 92 | at | Houston Chr 91 | |||
| 9 Feb | New Orleans 59 | at | Nicholls St 84 | |||
| 11 Feb | Nicholls St 88 | at | SE Louisiana 77 | |||
| 16 Feb | TAM C. Christi 78 | at | Nicholls St 74 | |||
| 18 Feb | Incarnate Word 74 | at | Nicholls St 84 | |||
| 20 Feb | TX A&M Commerce 72 | at | Nicholls St 71 | |||
| 23 Feb | Nicholls St 82 | at | New Orleans 88 | |||
| 25 Feb | Houston Chr 64 | at | Nicholls St 68 | |||
| 1 Mar | Lamar 60 | at | Nicholls St 64 | vs WAC | ||
| 6 Mar | McNeese St 77 | vs | Nicholls St 71 | Lake Charles, LA |
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