| Date | Res | Opp | OW-OL | ||
| 11/16/2008 | W 100-62 | Idaho | 16-15 | ||
| 11/19/2008 | W 70-59 | @ | IPFW | 12-16 | |
| 11/27/2008 | L 62-80 | vs | Maryland | 20-14 | |
| 11/28/2008 | W 94-79 | vs | Oklahoma St | 22-11 | |
| 11/30/2008 | W 65-57 | vs | Wichita St | 16-16 | |
| 12/3/2008 | L 63-98 | vs | North Carolina | 28-4 | |
| 12/7/2008 | W 75-59 | Bradley | 20-13 | ||
| 12/13/2008 | W 118-60 | Alcorn St | 4-23 | ||
| 12/17/2008 | W 79-65 | The Citadel | 18-12 | ||
| 12/20/2008 | W 67-63 | vs | Texas | 23-11 | |
| 12/27/2008 | W 82-66 | vs | Oakland | 22-12 | |
| 12/31/2008 | W 70-58 | @ | Minnesota | 21-8 | |
| 1/3/2009 | W 77-66 | @ | Northwestern | 16-13 | |
| 1/6/2009 | W 67-58 | Ohio State | 21-9 | ||
| 1/10/2009 | W 75-62 | Kansas | 27-6 | ||
| 1/14/2009 | W 78-73 | @ | Penn State | 24-10 | |
| 1/17/2009 | W 63-57 | Illinois | 24-8 | ||
| 1/21/2009 | L 63-70 | Northwestern | 16-13 | ||
| 1/25/2009 | W 78-67 | @ | Ohio State | 21-9 | |
| 1/29/2009 | W 71-56 | @ | Iowa | 15-15 | |
| 2/1/2009 | L 68-72 | Penn State | 24-10 | ||
| 2/4/2009 | W 76-47 | Minnesota | 21-8 | ||
| 2/7/2009 | W 75-47 | Indiana | 5-23 | ||
| 2/10/2009 | W 54-52 | @ | Michigan | 20-13 | |
| 2/17/2009 | L 54-72 | @ | Purdue | 26-9 | |
| 2/22/2009 | W 61-50 | Wisconsin | 19-12 | ||
| 2/25/2009 | W 62-54 | Iowa | 15-15 | ||
| 3/1/2009 | W 74-66 | @ | Illinois | 24-8 | |
| 3/3/2009 | W 64-59 | @ | Indiana | 5-23 | |
| 3/8/2009 | W 62-51 | Purdue | 26-9 | ||
| 3/13/2009 | W 64-56 | vs | Minnesota | 21-8 | Big Ten |
| 3/14/2009 | L 70-82 | vs | Ohio State | 21-9 | Big Ten |
| 3/20/2009 | W 77-62 | vs | Robert Morris | 24-10 | Midwest |
| 3/22/2009 | W 74-69 | vs | Southern California | 22-12 | Midwest |
| 28-6 | 465-295 |