| Date | Res | Opp | OW-OL | ||
| 11/12/2007 | W 58-37 | TX-San Antonio | 9-16 | ||
| 11/16/2007 | W 73-42 | UC Davis | 7-21 | Legends Classic | |
| 11/23/2007 | W 102-87 | vs | New Mexico St | 20-12 | Legends Classic |
| 11/24/2007 | W 97-78 | vs | Tennessee | 30-3 | Legends Classic |
| 11/28/2007 | W 98-61 | Texas Southern | 7-24 | ||
| 12/2/2007 | W 63-61 | @ | UCLA | 32-2 | Big 12-Pac 10 Challenge |
| 12/5/2007 | W 88-72 | North Texas | 17-10 | ||
| 12/8/2007 | W 80-54 | @ | Rice | 3-26 | |
| 12/15/2007 | W 96-81 | Texas St | 10-15 | ||
| 12/18/2007 | W 66-56 | Oral Roberts | 23-8 | ||
| 12/22/2007 | L 72-78 | vs | Michigan St | 26-8 | |
| 12/29/2007 | L 66-67 | Wisconsin | 30-4 | ||
| 1/2/2008 | W 67-59 | TCU | 13-15 | ||
| 1/5/2008 | W 81-62 | St. Mary's | 24-6 | ||
| 1/12/2008 | L 84-97 | @ | Missouri | 15-16 | |
| 1/19/2008 | W 69-67 | Colorado | 11-19 | ||
| 1/21/2008 | W 63-61 | @ | Oklahoma St | 16-12 | |
| 1/26/2008 | W 73-47 | Texas Tech | 14-14 | ||
| 1/30/2008 | L 63-80 | @ | Texas A&M | 23-10 | |
| 2/2/2008 | W 80-72 | Baylor | 20-9 | ||
| 2/6/2008 | W 64-54 | @ | Oklahoma | 23-9 | |
| 2/9/2008 | W 71-65 OT | @ | Iowa State | 13-17 | |
| 2/11/2008 | W 72-69 | Kansas | 31-2 | ||
| 2/16/2008 | W 82-77 | @ | Baylor | 20-9 | |
| 2/18/2008 | W 77-50 | Texas A&M | 23-10 | ||
| 2/23/2008 | W 62-45 | Oklahoma | 23-9 | ||
| 2/25/2008 | W 74-65 | @ | Kansas St | 20-11 | |
| 3/1/2008 | L 80-83 | @ | Texas Tech | 14-14 | |
| 3/4/2008 | W 70-66 | Nebraska | 19-11 | ||
| 3/9/2008 | W 62-57 | Oklahoma St | 16-12 | ||
| 3/14/2008 | W 66-59 | vs | Oklahoma St | 16-12 | Big 12 |
| 3/15/2008 | W 77-49 | vs | Oklahoma | 23-9 | Big 12 |
| 3/16/2008 | L 74-84 | vs | Kansas | 31-2 | Big 12 |
| 3/21/2008 | W 74-54 | vs | Austin Peay | 24-10 | South |
| 3/23/2008 | W 75-72 | vs | Non-Div I | 87-114 | South |
| 29-6 | 567-424 |