| 7 Nov | Ark Little Rock 63 | at | S Illinois 94 | vs OVC | ||
| 10 Nov | S Illinois 61 | at | Oklahoma St 60 | at B12 | ||
| 13 Nov | S Illinois 53 | at | Southern Indiana 71 | at OVC | ||
| 17 Nov | Tennessee St 44 | at | S Illinois 57 | vs OVC | ||
| 21 Nov | UNLV 56 | vs | S Illinois 49 | San Juan Capistrano, CA | vs MWC | |
| 23 Nov | S Illinois 64 | vs | Cal Baptist 61 | OT | San Juan Capistrano, CA | vs WAC |
| 30 Nov | S Illinois 80 | at | Evansville 53 | |||
| 3 Dec | S Illinois 72 | at | St Louis 85 | at A10 | ||
| 7 Dec | Indiana St 74 | at | S Illinois 71 | |||
| 10 Dec | Alcorn St 68 | at | S Illinois 74 | vs SWAC | ||
| 13 Dec | Lincoln MO 51 | at | S Illinois 88 | vs ND1 | ||
| 16 Dec | Chicago St 52 | at | S Illinois 63 | vs WAC | ||
| 21 Dec | S Illinois 70 | at | SE Missouri St 68 | at OVC | ||
| 29 Dec | S Illinois 63 | at | Murray St 57 | |||
| 1 Jan | Belmont 45 | at | S Illinois 63 | |||
| 4 Jan | Drake 49 | at | S Illinois 53 | |||
| 7 Jan | S Illinois 57 | at | Northern Iowa 69 | |||
| 11 Jan | S Illinois 69 | at | Indiana St 61 | |||
| 14 Jan | Illinois St 57 | at | S Illinois 69 | |||
| 17 Jan | Evansville 70 | at | S Illinois 78 | |||
| 21 Jan | S Illinois 61 | at | Missouri St 57 | |||
| 24 Jan | Murray St 64 | at | S Illinois 68 | |||
| 29 Jan | S Illinois 66 | at | Illinois St 72 | |||
| 1 Feb | S Illinois 52 | at | Bradley 62 | |||
| 5 Feb | Missouri St 53 | at | S Illinois 73 | |||
| 8 Feb | IL Chicago 66 | at | S Illinois 68 | |||
| 11 Feb | S Illinois 59 | at | Drake 82 | |||
| 14 Feb | S Illinois 66 | at | Valparaiso 62 | |||
| 19 Feb | Bradley 50 | at | S Illinois 48 | |||
| 22 Feb | Northern Iowa 63 | at | S Illinois 86 | |||
| 26 Feb | S Illinois 68 | at | IL Chicago 65 | |||
| 3 Mar | S Illinois 54 | vs | Missouri St 51 | St. Louis, MO | ||
| 4 Mar | Drake 65 | vs | S Illinois 52 | St. Louis, MO |
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