| Date | Res | Opp | OW-OL | ||
| 11/13/2009 | W 82-53 | Jackson St | 18-11 | ||
| 11/17/2009 | L 55-57 | vs | Kansas | 31-2 | Hall of Fame Classic |
| 11/20/2009 | W 92-59 | Tennessee Tech | 13-16 | Hall of Fame Classic | |
| 11/24/2009 | W 81-49 | Central Arkansas | 5-20 | Hall of Fame Classic | |
| 11/30/2009 | W 77-46 | Oakland | 24-7 | Hall of Fame Classic | |
| 12/5/2009 | W 74-55 | Arkansas St | 15-13 | ||
| 12/9/2009 | W 76-51 | Montana St | 14-13 | ||
| 12/12/2009 | W 83-71 | @ | UA Little Rock | 6-21 | |
| 12/19/2009 | L 72-73 | @ | Massachusetts | 9-21 | |
| 12/22/2009 | W 87-57 | SE Missouri St | 6-23 | ||
| 12/28/2009 | W 87-67 | IUPUI | 22-9 | ||
| 12/31/2009 | L 59-66 | Tennessee | 24-8 | ||
| 1/3/2010 | W 93-52 | Houston Baptist | 12-20 | ||
| 1/6/2010 | L 57-74 | @ | Syracuse | 27-3 | |
| 1/9/2010 | W 59-57 | @ | Southern Miss | 16-11 | |
| 1/13/2010 | W 77-57 | East Carolina | 7-20 | ||
| 1/16/2010 | W 80-68 | @ | Rice | 7-22 | |
| 1/20/2010 | L 67-72 | UTEP | 25-6 | ||
| 1/23/2010 | W 92-77 | Houston | 16-14 | ||
| 1/27/2010 | W 75-72 | @ | Marshall | 20-8 | |
| 1/30/2010 | L 60-70 | @ | SMU | 12-15 | |
| 2/3/2010 | W 85-75 | UAB | 24-5 | ||
| 2/6/2010 | L 58-66 | Gonzaga | 24-6 | ||
| 2/10/2010 | W 76-70 | UCF | 13-16 | ||
| 2/13/2010 | W 93-86 | @ | Tulsa | 22-10 | |
| 2/17/2010 | W 77-64 | @ | Tulane | 7-22 | |
| 2/20/2010 | W 76-63 | SMU | 12-15 | ||
| 2/24/2010 | L 75-92 | @ | Houston | 16-14 | |
| 2/27/2010 | W 76-69 | Southern Miss | 16-11 | ||
| 3/3/2010 | W 70-65 | @ | UAB | 24-5 | |
| 3/6/2010 | L 58-66 | Gonzaga | 24-6 | ||
| 3/11/2010 | L 65-66 | vs | Houston | 16-14 | Conference USA |
| 22-10 | 419-342 |